82657-70-3

Usage

Uses

Used in Pharmaceutical Industry:
(4-propylphenyl)Methanol is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and improve the efficacy of existing ones.
Used in Fragrance Industry:
(4-propylphenyl)Methanol is used as a fragrance ingredient in personal care products and perfumes for its aromatic properties, enhancing the scent profiles of these products.
Used in Polymer and Resin Production:
(4-propylphenyl)Methanol is used in the production of polymers and resins for its ability to improve the properties of these materials, such as durability and stability.
Used in Organic Compound Synthesis:
(4-propylphenyl)Methanol is used as a building block in the synthesis of various organic compounds for its versatility in forming different chemical structures and enhancing their properties.

Upstream product

• 2438-05-3 4-n-propylbenzoic acid 
• 52710-27-7 4-propylbenzoyl chloride 
• 87736-74-1 4-(tert-butyldimethylsiloxymethyl)bromobenzene 
• 1004992-92-0 1-(4-(hydroxymethyl)phenyl)propan-1-ol 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1360803-32-2 tert-butyldimethyl((4-propylbenzyl)oxy)silane 
• 1360803-31-1 tert-butyldimethyl((4-(prop-1-yn-1-yl)benzyl)oxy)silane 
• 1093190-17-0 tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane 
• 275386-60-2 4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene 
• 1093190-16-9 [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane 
• 28785-06-0 4-n-propylbenzaldehyde 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 

Downstream Products

• 126156-22-7 (2-Iodo-4-propyl-phenyl)-methanol 
• 91062-39-4 1-(Bromomethyl)-4-propylbenzene 
• 1360803-33-3 1-(iodomethyl)-4-propylbenzene 
• 1360803-34-4 methyl 2-((4-propylbenzyl)amino)acetate 
• 26114-12-5 2-(4-propylphenyl)acetic acid 
• 1360803-35-5 methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate 
• 1360803-36-6 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid 
• 1512864-35-5 (4-(3,3-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl)phenyl)methanol 
• 1224716-84-0 4-propylbenzyl methanesulfonate 
• 1224714-75-3 N-(1-{6-[(4-propylbenzyl)oxy]-1-benzofuran-3-yl}ethyl)acetamide 
• 3166-97-0 1-(Chloromethyl)-4-propylbenzene 
• 126156-30-7 2-iodoso-4-n-propylbenzoic acid 
• 126156-25-0 2-iodo-4-n-propyl-benzoic acid 
• 3166-98-1 (4-n-propylphenyl)acetonitrile 

Relevant academic research and scientific papers

Chemoselective Deoxygenation of 2° Benzylic Alcohols through a Sequence of Formylation and B(C6F5)3-Catalyzed Reduction

A sequence of formylation and B(C6F5)3-catalyzed reduction of the resulting formate with Et3SiH enables the chemoselective deoxygenation of secondary benzylic alcohols. Primary benzylic and tertiary non-benzylic alcohols are not reduced by this protocol. The formyl group fulfills a double role as activator and self-sacrificing protecting group. The deoxygenation of these formates is fast and can be carried out in the presence of other potentially reducible groups. Neighboring-group participation was found in the deoxygenation of certain diol motifs.

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies

4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate (3b) is a potent, selective and systemically active inhibitor of intracellular NAAA activity, which produces profound anti-inflammatory effects in animal models. In the present work, we describe structure-activity relationship (SAR) studies on 3-aminoazetidin-2-one derivatives, which have led to the identification of 3b, and expand these studies to elucidate the principal structural and stereochemical features needed to achieve effective NAAA inhibition. Investigations on the influence of the substitution at the β-position of the 2-oxo-3-azetidinyl ring as well as on the effect of size and shape of the carbamic acid ester side chain led to the discovery of 3ak, a novel inhibitor of human NAAA that shows an improved physicochemical and drug-like profile relative to 3b. This favourable profile, along with the structural diversity of the carbamic acid chain of 3b, identify this compound as a promising new tool to investigate the potential of NAAA inhibitors as therapeutic agents for the treatment of pain and inflammation.

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathological conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile (14) was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacological tools and their potential development as drug leads.

BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.

Palladium(0)-catalyzed cross-coupling of 1,1-diboronates with vinyl bromides and 1,1-dibromoalkenes

Palladium-catalyzed cross-coupling reactions of 1,1-diboronates with vinyl bromides and dibromoalkenes were found to afford 1,4-dienes and allenes, respectively. These reactions utilize the high reactivities of both 1,1-diboronates and allylboron intermediates generated in the initial coupling.

CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

Electrophilicity and nucleophilicity of commonly used aldehydes

The present approach for determining the electrophilicity (E) and nucleophilicity (N) of aldehydes includes a kinetic study of KMNO4 oxidation and NaBH4 reduction of aldehydes. A transition state analysis of the KMNO4 promoted aldehyde oxidation reaction has been performed, which shows a very good correlation with experimental results. The validity of the experimental method has been tested using the experimental activation parameters of the two reactions. The utility of the present approach is further demonstrated by the theoretical versus experimental relationship, which provides easy access to E and N values for various aldehydes and offers an at-a-glance assessment of the chemical reactivity of aldehydes in various reactions. the Partner Organisations 2014.

LABELING AGENT AND AMINO ACID SEQUENCE USING SAME, AND METHOD FOR PERFORMING SIMULTANEOUS QUANTITATIVE ANALYSIS OF MULTIPLE PROTEINS

The present invent ion provides a compound that can utilize hydrogen isotope and, at the same time, can quantify multiplexed samples at one time, as well as decreasing the cost for synthesis of the labeling agent. In addition, the present invention provid

Making a difference on excited-state chemistry by controlling free space within a nanocapsule: Photochemistry of 1-(4-alkylphenyl)-3-phenylpropan-2-ones

The free space within a reaction cavity plays a determining role during the excited-state reaction of 1-(4-alkylphenyl)-3-phenylpropan-2-ones included within a capsule formed by two molecules of a deep cavity cavitand. By controlling the free space within the reaction cavity through remote alkyl substitution on the reactant ketone it is possible to control the yield of the rearrangement product shown above.

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.