275386-75-9 Usage
Description
1,3-dihydro-5-fluoro-4-iodo-2H-indol-2-one is a synthetic chemical compound derived from the indole family, characterized by the incorporation of a fluorine and an iodine atom into its structure. This modification endows the compound with distinct properties and potential biological activities, positioning it as a candidate for pharmaceutical applications in medicinal chemistry and pharmacology.
Uses
Used in Pharmaceutical Development:
1,3-dihydro-5-fluoro-4-iodo-2H-indol-2-one is utilized as a chemical intermediate in the design and development of new drugs, leveraging its unique structural features to explore novel therapeutic agents. The presence of fluorine and iodine atoms may confer specific pharmacokinetic and pharmacodynamic properties, such as enhanced lipophilicity or target binding affinity, which are crucial for drug efficacy and safety.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1,3-dihydro-5-fluoro-4-iodo-2H-indol-2-one serves as a valuable probe for studying the structure-activity relationships of indole-based compounds. Its synthesis and modification can provide insights into the role of heteroatoms in modulating biological activity, thereby guiding the optimization of lead compounds for various therapeutic targets.
Used in Pharmacological Studies:
1,3-dihydro-5-fluoro-4-iodo-2H-indol-2-one is employed in pharmacological research to investigate its potential biological activities and mechanisms of action. Given its structural novelty, this compound may exhibit unforeseen interactions with biological targets, offering opportunities to discover new modes of action or therapeutic indications.
Check Digit Verification of cas no
The CAS Registry Mumber 275386-75-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,5,3,8 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 275386-75:
(8*2)+(7*7)+(6*5)+(5*3)+(4*8)+(3*6)+(2*7)+(1*5)=179
179 % 10 = 9
So 275386-75-9 is a valid CAS Registry Number.
275386-75-9Relevant articles and documents
A new series of potent oxindole inhibitors of CDK2
Luk, Kin-Chun,Simcox, Mary Ellen,Schutt, Andy,Rowan, Karen,Thompson, Thelma,Chen, Yi,Kammlott, Ursula,DePinto, Wanda,Dunten, Pete,Dermatakis, Apos
, p. 913 - 917 (2004)
A novel series of oxindole-type inhibitors of CDK2 that have heteroatom substituted alkynyl moieties at their C-4 position is described. These novel 4-alkynyl-substituted inhibitors have superior potency relative to their parent compound in free enzyme and in cell based assays. The crystal structure of CDK2 in complex with one of these analogues was determined and gives insight to their increased potency. The biochemical evaluation of a representative derivative is also described.
PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF
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Page/Page column 99, (2010/04/23)
The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, espe
4-Alkenyl- and 4-alkynyloxindoles
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, (2008/06/13)
Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.
