27542-41-2

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Chloro-D-tryptophan is utilized as a key building block for the synthesis of various biologically active compounds, contributing to the advancement of new pharmaceuticals and the understanding of biological processes.
Used in Cancer Research:
In the field of cancer research, 4-Chloro-D-tryptophan is employed for its potential therapeutic applications, aiding in the development of novel treatments and enhancing the understanding of cancer-related biological mechanisms.
Used in Drug Development:
4-Chloro-D-tryptophan plays a crucial role in drug development, serving as a component in the creation of new medications designed to target specific diseases, including cancer, by leveraging its unique chemical properties to improve therapeutic efficacy and selectivity.

Upstream product

• 40247-57-2 4-chloro-3-dimethylaminomethylindole 
• 1906-82-7 ethyl acetamidoacetate 
• 95-92-1 oxalic acid diethyl ester 
• 147663-90-9 acetylamino-(4-chloro-indol-3-ylmethyl)-malonic acid diethyl ester 
• 25235-85-2 4-chloro-1H-indole 
• 83-42-1 6-chloro-2-nitrotoluene 
• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 
• 63352-98-7 4-chloro-3-diethylaminomethylindole 
• 100376-53-2 2-(2-amino-6-chlorophenyl)ethyl alcohol 
• 24621-73-6 4-chloro-1H-indole-2-carboxylic acid 
• 56-45-1 L-serin 

Downstream Products

• 2447-16-7 2-(4-chloro-1H-indol-3-yl)ethanamine 

Relevant academic research and scientific papers

De novo Biosynthesis of “Non-Natural” Thaxtomin Phytotoxins

Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity and novel mode of action there has been considerable interest in developing thaxtomins as herbicides for crop protection. To address the need for more stable derivatives, we have developed a new approach for structural diversification of thaxtomins. Genes encoding the thaxtomin NRPS from S. scabies, along with genes encoding a promiscuous tryptophan synthase (TrpS) from Salmonella typhimurium, were assembled in a heterologous host Streptomyces albus. Upon feeding indole derivatives to the engineered S. albus strain, tryptophan intermediates with alternative substituents are biosynthesized and incorporated by the NRPS to deliver a series of thaxtomins with different functionalities in place of the nitro group. The approach described herein, demonstrates how genes from different pathways and different bacterial origins can be combined in a heterologous host to create a de novo biosynthetic pathway to “non-natural” product target compounds.

ANTIBACTERIAL COMPOUNDS

Novel compounds having antimicrobial activitiy, in particular against Pseudomonas aeruginosa, Burkholderia cepaciaand/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.

L-4-Chlorotryptophan from Immature Seeds of Pisum sativum and Reassignment of the Absolute Stereochemistry of N-Malonyl-4-chlorotryptophan

Free 4-chlorotryptophan (4-Cl-Trp) was isolated from immature seeds of P. sativum, identified, and its stereochemistry determined to be L-form.Reinvestigation of the N-malonyl-4-Cl-Trp isolated from the same seeds showed that the stereochemistry of the 4-Cl-Trp residue is L-form.