27579-58-4

Basic information

• Product Name: 5,6,7,8-Tetrahydroquinoxalin-2-ol
• Synonyms: 5,6,7,8-Tetrahydroquinoxalin-2-ol
• CAS NO: 27579-58-4
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.1778
• Mol File: 27579-58-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 449.9°C at 760 mmHg
• Flash Point: 225.9°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 1.04E-08mmHg at 25°C
• Refractive Index: 1.666
• PKA: 12.81±0.20(Predicted)
• CAS DataBase Reference: 5,6,7,8-Tetrahydroquinoxalin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-Tetrahydroquinoxalin-2-ol(27579-58-4)
• EPA Substance Registry System: 5,6,7,8-Tetrahydroquinoxalin-2-ol(27579-58-4)

Safety Data

• Hazardous Substances Data: 27579-58-4(Hazardous Substances Data)

Usage

General Description

5,6,7,8-Tetrahydroquinoxalin-2-ol is a chemical compound with the molecular formula C9H11N2O. It is a heterocyclic compound containing a quinoxaline ring. 5,6,7,8-Tetrahydroquinoxalin-2-ol is commonly used as a building block in organic synthesis and pharmaceutical research. It has also been studied for its potential use in medicinal and pharmaceutical applications, particularly in the development of new drugs. Additionally, 5,6,7,8-Tetrahydroquinoxalin-2-ol has been investigated for its potential biological activities, including its effects on the central nervous system. Overall, this chemical compound has attracted attention for its diverse potential uses in both organic synthesis and medicinal chemistry.

InChI:InChI=1/C8H10N2O/c11-8-5-9-6-3-1-2-4-7(6)10-8/h5H,1-4H2,(H,10,11)

Upstream product

• 1668-10-6 glycinamide hydrochloride 
• 765-87-7 cyclohexane-1,2-dione 
• 598-41-4 H-Gly-NH₂ 
• 106867-69-0 1-hydroxy-5,6,7,8-tetrahydro-2(1H)-quinoxalinone 
• 177938-61-3 1-benzyloxy-5,6,7,8-tetrahydro-2(1H)-quinoxalinone 

Downstream Products

• 155535-20-9 2-chloro-5,6,7,8-tetrahydroquinoxaline 

Relevant articles and documents

2-alkoxy-5,6,7,8-tetrahydroquinoxaline derivatives, and production method and use thereof

Disclosed are a compound represented by formula (1) and a non-toxic salt thereof, a production method thereof, and a pharmaceutical composition for treating a serotonergic neuron-related disease comprising the same as an active ingredient: STR1 wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents a pyridyl group which is unsubstituted or substituted with 1 to 3 substituents each independently selected from the group consisting of a halogen atom, a lower alkyl group, a trifluoromethyl group, a lower alkoxy group, a carbamoyl group and a cyano group, or a pyrimidinyl group which is unsubstituted or substituted with 1 to 2 substituents each independently selected from the group consisting of a lower alkyl group and a lower alkoxy group; and n is an integer of from 2 to 5. Compound (1) of the present invention and a non-toxic salt thereof have a strong affinity for serotonin 1A receptor and, therefore, they are useful for preventing and treating serotonergic neuron-related diseases, such as motion sickness, space sickness, emesis, dizziness, depression, anxiety, eating disorder, and the like.

Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands

The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 where W represents an aromatic group substituted with various organic and inorganic substituents;X, Y are hydrogen, halogen, hydroxy or amino with the proviso that at least X or Y is hydroxy;A, B C, and D, represent nitrogen or a carbon atom substituted with various organic and inorganic substituents;E represents oxygen, sulfur or substituted nitrogen;R 3, R 4, R 12, and R 13 are variables representing various organic and inorganic substituents; andn is 0, 1, or 2.