27593-80-2

Upstream product

• 4463-02-9 2,4-dimethylbenzene-1,3,5-triol 
• 102-92-1 Cinnamoyl chloride 
• 13383-63-6 1-(2,4,6-trihydroxy-3,5-dimethylphenyl)ethan-1-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 51621-52-4 5-hydroxy-7-methoxy-6,8-dimethylflananone 
• 65349-33-9 7-acetoxy-5-hydroxy-6,8-dimethyl-2-phenyl-chroman-4-one 
• 65349-34-0 2',4',6'-Triacetoxy-3',5'-dimethylchalcon 

Relevant academic research and scientific papers

Synthesis and biological activity of flavanone derivatives

A series of new flavanone derivatives of farrerol was synthesized by a convenient method. The in vitro anti-tumor activity of these compounds was evaluated against human Bel-7402, HL-60, BGC-823 and KB cell lines, the protein tyrosine kinase (PTK) inhibitor activity was also tested. Their cytoprotective activity was tested using hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells. Their in vitro anti-atherosclerosis activity was tested on vascular smooth muscle cells by the MTT method using tetrandrine as a positive contrast drug. The structures of all compounds synthesized were confirmed by 1H, 13C NMR and ESI-MS. Most of the compounds exhibited good pharmacological activity and the preliminary structure-activity relationships were described.