27610-27-1

Usage

Uses

Used in Pharmaceutical Industry:
Solerole is used as an alkylating agent for the modification of proteins. Its ability to alkylate proteins allows for the development of new drugs and therapeutic agents that can target specific biological processes.
Used in Chemical Research:
In the field of chemical research, Solerole is used as a reagent for the alkylation of proteins and other biomolecules. This helps researchers understand the structure and function of these molecules, as well as their interactions with other cellular components.
Used in Diagnostic Applications:
Solerole can be employed in the development of diagnostic tools and tests, where the alkylation of proteins can be used to detect specific biomarkers or to study protein modifications related to certain diseases.
Used in Biochemical Applications:
In the realm of biochemistry, Solerole is used as a tool for the alkylation of proteins, which can help in the study of enzyme mechanisms, protein-protein interactions, and other biological processes.
Overall, Solerole is a versatile compound with a wide range of applications in various industries, primarily due to its ability to alkylate proteins and other biomolecules.

InChI:InChI=1/C6H10O4/c7-4-1-2-6(9)10-3-5(4)8/h4-5,7-8H,1-3H2

Upstream product

• 598-32-3 2-hydroxy-3-butene 
• 144-48-9 iodacetamide 
• 34495-74-4 Ethyl 4-hexenoate 
• 1577-20-4 (E)-hex-4-enoic acid 
• 41143-12-8 hex-4-ynoic acid 
• 6089-09-4 4-pentynoic acid 
• 124558-70-9 (S)-4-Ethylsulfanyl-5-((S)-1-hydroxy-ethyl)-5H-furan-2-one 

Downstream Products

• 89158-15-6 p-nitrobenzoate of L-(+)-rhodinono-γ-lactone 
• 89158-14-5 p-nitrobenzoate of D-(+)-amicetono-γ-lactone 
• 876152-53-3 2-((2S,3R,6S)-6-{(E)-(S)-3-[(2R,3S,5R)-5-((S)-1-Methoxy-ethyl)-3-methyl-tetrahydro-furan-2-yl]-but-1-enyl}-3-methyl-tetrahydro-pyran-2-yl)-ethanol 
• 130258-63-8 (3R,5R)-5-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-dihydro-furan-2-one 
• 130258-63-8 (3S,5R)-5-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-dihydro-furan-2-one 
• 130323-45-4 (R)-5-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-dihydro-furan-2-one 
• 54656-51-8 (R)-5-((S)-1-hydroxyethyl)dihydrofuran-2(3H)-one 
• 876152-44-2 tert-Butyl-[2-((2S,3R,6S)-6-{(E)-(S)-3-[(2S,3S,5R)-5-((S)-1-methoxy-ethyl)-3-methyl-tetrahydro-furan-2-yl]-but-1-enyl}-3-methyl-tetrahydro-pyran-2-yl)-ethoxy]-diphenyl-silane 
• 876152-52-2 tert-Butyl-[2-((2S,3R,6S)-6-{(E)-(S)-3-[(2R,3S,5R)-5-((S)-1-methoxy-ethyl)-3-methyl-tetrahydro-furan-2-yl]-but-1-enyl}-3-methyl-tetrahydro-pyran-2-yl)-ethoxy]-diphenyl-silane 
• 876152-35-1 tert-Butyl-((2R,3R,6S)-6-{(E)-(S)-3-[(2S,3S,5R)-5-((S)-1-methoxy-ethyl)-3-methyl-tetrahydro-furan-2-yl]-but-1-enyl}-3-methyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane 
• 876152-50-0 tert-Butyl-((2R,3R,6S)-6-{(E)-(S)-3-[(2R,3S,5R)-5-((S)-1-methoxy-ethyl)-3-methyl-tetrahydro-furan-2-yl]-but-1-enyl}-3-methyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane 
• 876152-48-6 (S)-1-((2R,4S)-4-Methyl-5-phenylsulfanyl-tetrahydro-furan-2-yl)-ethanol 
• 876152-41-9 (3S,5R)-5-((S)-1-Methoxy-ethyl)-3-methyl-2-phenylsulfanyl-tetrahydro-furan 
• 876152-40-8 (S)-1-((R)-5-oxotetrahydrofuran-2-yl)ethyl 4-nitrobenzoate 

Relevant academic research and scientific papers

Synthesis of the C14-C28 fragment of tetronasin

A synthesis of the C14-C28 fragment of Tetronasin features an S E2 reaction between a cationic η3-allylmolybdenum complex and and an α-metallated tetrahydrofuran. Georg Thieme Verlag Stuttgart.

Radical addition of 2-iodoalkanamide or 2-iodoalkanoic acid to alkenes with a water-soluble radical initiator in aqueous media: Facile synthesis of γ-lactones

Radical reactions in water or aqueous ethanol using a water-soluble radical initiator are described. Heating a mixture of 2-iodoacetamide and 5-hexen-1-ol in water at 75 °C in the presence of a water-soluble radical initiator, 4,4′-azobis 4-cyanopentanoic acid), afforded 5-(4-hydroxybutyl)dihydrofuran-2(3H)-one in 95% yield. The use of 2-iodoacetic acid in place of 2-iodoacetamide also gave the same γ-lactone in 93% yield. The reaction of 2-iodoacetamide with 1-octene in aqueous ethanol was initiated by 2,2′-azobis(2-methylpropanamidine) dihydrochloride to provide γ-decanolactone. Employing water as a solvent is crucial to obtain lactone in satisfactory yield.

(+/-)-erythro-γ,δ-Dihydroxycarboxylic Acid Lactones from a β-Lithiopropionate Equivalent and α-Chloroaldehydes

Reaction of β-ethylthio-β-lithioacrylate 1A with α-chloroaldehydes furnished predominantly the erythro products 3, which were isolated as γ-lactones 4.At room temperature intermediates 3 are transformed into the (+/-)-erythro-γ,δ-dihydroxycarboxylic acid γ-lactones 8.Raney nickel treatment provided interesting natural γ-lactone derivatives; thus, from erythro-8c the socalled L-factor erythro-9c was obtained.Similarly, from β-methoxy β-lithioacrylate 10A the (+/-)-erythro-γ,δ-dihydroxycarboxylic acid δ-lactone erythro-11 was gained.

A Simple, General Diastereoselective Synthesis of 5-Hydroxyalkylbutan-4-olides

cis- and trans-Hex-4-enoic acids and their 6-n-propyl and n-butyl derivatives, when treated with a 1.1 molar excess of m-chloroperbenzoic acid and Amberlyst-15 as catalyst in CH2Cl2 at 20 deg C, gave the corresponding threo- and erythro-5-hydroxyalkylbutan-4-olides in quantitative yields.