276259-95-1Relevant academic research and scientific papers
Biphenyls as potent vitronectin receptor antagonists. Part 2: Biphenylalanine ureas
Urbahns, Klaus,Haerter, Michael,Vaupel, Andrea,Albers, Markus,Schmidt, Delf,Brueggemeier, Ulf,Stelte-Ludwig, Beatrix,Gerdes, Christoph,Tsujishita, Hideki
, p. 1071 - 1074 (2003)
Vitronectin receptor (αVβ3) antagonism has been implicated in a variety of disease states, like restenosis, osteoporosis and cancer. In this work, we present the development of a novel class of biphenyl vitronectin receptor antagonists. Identified from a focused combinatorial library based on para-bromo phenylalanine, these compounds show nanomolar affinity to the vitronectin receptor and display unprecedented SAR. Their binding mode can be rationalized by computational docking studies using the X-ray structure of αVβ3.
NEW BIPHENYL AND BIPHENYL-ANALOGOUS COMPOUNDS AS INTEGRIN ANTAGONISTS
-
Page/Page column 156; 170, (2010/02/13)
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophyl
