2763-66-8

Usage

General Description

N-CYCLOHEXYL-5-CHLOROVALERAMIDE is a chemical compound with the molecular formula C11H19ClNO. It is a white to off-white crystalline powder that is used as an intermediate in the production of various pharmaceuticals and agrochemicals. N-CYCLOHEXYL-5-CHLOROVALERAMIDE is known for its ability to act as a benzodiazepine receptor ligand, which makes it useful in the development of medications for anxiety, insomnia, and other neurological disorders. It also has pesticidal properties, making it valuable in the development of crop protection products. N-CYCLOHEXYL-5-CHLOROVALERAMIDE is considered to be a versatile and important building block in the production of various chemical products.

InChI:InChI=1/C11H21NO/c1-2-3-9-11(13)12-10-7-5-4-6-8-10/h10H,2-9H2,1H3,(H,12,13)

Upstream product

• 38291-82-6 valeric acid hydrazide 
• 108-91-8 cyclohexylamine 
• 638-29-9 n-valeryl chloride 
• 110-83-8 cyclohexene 
• 2082-59-9 pentanoic anhydride 
• 110-59-8 pentanonitrile 
• 110-82-7 cyclohexane 
• 76-05-1 trifluoroacetic acid 
• 76-03-9 trichloroacetic acid 
• 62-23-7 4-nitro-benzoic acid 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 109-52-4 valeric acid 

Relevant academic research and scientific papers

Metal-free Photocatalytic Intermolecular anti-Markovnikov Hydroamination of Unactivated Alkenes

The development of photocatalytic intermolecular hydroamination reaction between N-aminated dihydropyridines and unactivated alkenes is reported. Metal-free co-catalysts, rhodamine 6G and thiophenol, in presence of visible light are used to initiate the process. The transformation shows a broad substrate scope, both alkenes and amidyl radical can act as coupling partners. The radical strategy provides excellent anti-Markovnikov selectivity and regioselectivity in diene substrates.

Selective α-Oxyamination and Hydroxylation of Aliphatic Amides

Compared to the α-functionalization of aldehydes, ketones, even esters, the direct α-modification of amides is still a challenge because of the low acidity of α-CH groups. The α-functionalization of N?H (primary and secondary) amides, containing both an unactived α-C?H bond and a competitively active N?H bond, remains elusive. Shown herein is the general and efficient oxidative α-oxyamination and hydroxylation of aliphatic amides including secondary N?H amides. This transition-metal-free chemistry with high chemoselectivity provides an efficient approach to α-hydroxy amides. This oxidative protocol significantly enables the selective functionalization of inert α-C?H bonds with the complete preservation of active N?H bond.

N-Acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides: Highly selective and efficient reagents for acylation of amines in water

A variety of N-acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides (1a-e) were synthesized in one pot from 4-chloroaniline under solvent-free conditions and have been developed as chemoselective N-acylation reagents. Selective protection of primary amines in the presence of secondary amines, acylation of aliphatic amines in the presence of aryl amines, and monofunctionalization of primary-secondary diamines as well as selective N-acylation of amino alcohols using these reagents are described. All of the acylation reactions were carried out in water as a green solvent. High stability and easy preparation of these acylating reagents are other advantages of this method.

Copper-catalyzed oxidative esterification of unactivated C(sp3)-H bonds with carboxylic acids via cross dehydrogenative coupling

An effective copper-catalyzed esterification of unactivated (non-benzylic and allylic) C(sp3)-H bonds of hydrocarbons with Selectfluor as an oxidant has been developed. This reaction could provide a direct, new and useful strategy for the synthesis of esters and alkyl alcohols by ester hydrolysis.

THE DIRECT CONVERSION OF CARBOXYLIC ACIDS TO CARBOXAMIDES VIA REACTION WITH UNSOLVATED BIS(DIORGANOAMINO) MAGNESIUM REAGENTS

It has been found that unsolvated bis(diorganoamino) magnesium compounds react smoothly with carboxylic acids to give the corresponding carboxamides directly in good to excellent yields.