27654-05-3

Basic information

• Product Name: 9-hydrazinylacridine
• Synonyms: 9-HYDRAZINOACRIDINE; acridine, 9-hydrazinyl-
• CAS NO: 27654-05-3
• Molecular Formula: C₁₃H₁₁N₃
• Molecular Weight: 209.2465
• Mol File: 27654-05-3.mol

Chemical Properties

• Boiling Point: 475.9°C at 760 mmHg
• Flash Point: 241.6°C
• Density: 1.328g/cm³
• Vapor Pressure: 3.19E-09mmHg at 25°C
• Refractive Index: 1.819
• CAS DataBase Reference: 9-hydrazinylacridine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-hydrazinylacridine(27654-05-3)
• EPA Substance Registry System: 9-hydrazinylacridine(27654-05-3)

Safety Data

• Hazardous Substances Data: 27654-05-3(Hazardous Substances Data)

Upstream product

• 110166-26-2 aminacrine 
• 1207-69-8 9-Chloroacridine 

Downstream Products

• 116923-74-1 4-(Acridin-9-yl-hydrazonomethyl)-phenylamine 
• 91074-09-8 N-Acridin-9-yl-N'-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 98081-05-1 N-Acridin-9-yl-N'-[1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 98081-06-2 N-Acridin-9-yl-N'-[1-(2,6-dichloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 91627-28-0 N-Acridin-9-yl-N'-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 91627-29-1 N-Acridin-9-yl-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 98081-00-6 4-(Acridin-9-yl-hydrazonomethyl)-phenol 
• 98081-01-7 N-Acridin-9-yl-N'-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 98080-98-9 2-(Acridin-9-yl-hydrazonomethyl)-phenol 
• 116923-71-8 N-Acridin-9-yl-N'-[1-(2,4-dichloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 98081-02-8 4-(Acridin-9-yl-hydrazonomethyl)-2-methoxy-phenol 
• 116923-77-4 N-Acridin-9-yl-N'-[1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 116923-76-3 N-Acridin-9-yl-N'-[1-(3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 116923-75-2 N-Acridin-9-yl-N'-[1-(2-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 

Relevant articles and documents

Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity

A rapid preparation of compounds (1-24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o. The compound 1-(2′,4′-Chloroacridine-9′-yl)-3-(5′-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o.

Synthesis and antiproliferative activity of new hybrids bearing neocryptolepine, acridine and α-aminophosphonate scaffolds

Synthesis of novel α-aminophosphonate hybrids 8a–f was accomplished by the reaction of 11-phenoxy-4-formylneocryptolepine 3, aminoalkylamino acridines 6a–f and diphenyl phosphite 7 in the presence of lithium perchlorate as Lewis acid catalyst in methanol.

Design, synthesis and evaluation of acridin-9-yl hydrazide derivatives as BACE-1 inhibitors

BACE-1, an aspartyl protease is implicated in Alzheimer’s disease. In this paper, we report BACE-1 inhibitory potential of acridin-9-yl hydrazide derivatives, known to inhibit other aspartyl proteases. The derivatives were designed based on the docking st

Stereochemistry, tautomerism, and reactions of acridinyl thiosemicarbazides in the synthesis of 1,3-thiazolidines

Acridin-9-yl hydrazine upon treatment with various isothiocyanates (RNCS, R = methyl, allyl, phenyl, p-methoxy phenyl, and p-nitro phenyl) yielded the corresponding thiosemicarbazides with acridine substituted on the carbazide-type side. The alkyl-substit