2766-42-9Relevant articles and documents
A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.
Goldberg, Joel A.,Kumar, Vijay,Spencer, Elizabeth J.,Hoyer, Denton,Marshall, Steven H.,Hujer, Andrea M.,Hujer, Kristine M.,Bethel, Christopher R.,Papp-Wallace, Krisztina M.,Perez, Federico,Jacobs, Michael R.,van Duin, David,Kreiswirth, Barry N.,van den Akker, Focco,Plummer, Mark S.,Bonomo, Robert A.
, (2021)
Serious infections caused by multidrug-resistant (MDR) organisms (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii) present a critical need for innovative drug development. Herein, we describe the preclinical evaluation of YU253911,
SIDEROPHORE CONJUGATED PYRAZOLIDINONES, AND ANALOGUES THEREOF
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Page/Page column 21, (2020/02/14)
In one aspect, the invention provides compounds and methods that are useful for treating bacterial infections.
Synthesis method of benserazide hydrochloride
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Paragraph 0126; 0127; 0130; 0131, (2019/12/11)
The invention relates to a synthesis method of benserazide hydrochloride. According to the synthesis method, serine methyl ester hydrochloride is taken as the primary raw material, at first, amino protection reactions are carried out; and then amine-ester exchange reactions, condensation reactions, reduction reactions, and de-protection reactions are performed to obtain high purity benserazide hydrochloride. The synthesis method has the advantages that the raw materials are cheap and easily available, the operation is convenient, the product purity and yield of each step are high, and thus thesynthesis method is suitable for industrial production.