27678-61-1

Basic information

• Product Name: Piperazine,1-(6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-methyl- (8CI,9CI)
• Synonyms: Dibenz[b,e]oxepin,piperazine deriv.; Perazoxin
• CAS NO: 27678-61-1
• Molecular Formula: C19H22 N2 O
• Molecular Weight: 294.396
• Mol File: 27678-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperazine,1-(6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-methyl- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine,1-(6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-methyl- (8CI,9CI)(27678-61-1)
• EPA Substance Registry System: Piperazine,1-(6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-methyl- (8CI,9CI)(27678-61-1)

Safety Data

• Hazardous Substances Data: 27678-61-1(Hazardous Substances Data)

Upstream product

• 5251-26-3 11-hydroxy-6,11-dihydrodibenzo[b,e]oxepine 
• 109-01-3 1-methyl-piperazine 
• 19373-88-7 11-chloro-6,11-dihydrodibenzo[b,e]oxepine 
• 21733-94-8 2-phenoxymethylbenzoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 87-24-1 ethyl 2-methylbenzoate 
• 7115-91-5 2-ethoxycarbonylbenzyl bromide 
• 4504-85-2 2-Phenoxymethyl-benzoic acid ethyl ester 
• 724-98-1 2-(phenoxymethyl)benzoic acid 
• 4504-87-4 6,11-dihydrodibenz[b,e]oxepin-11-one 

Relevant articles and documents

Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs

Inspired by VUF6884 (7-Chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine), reported as a dual H1/H4 receptor ligand (pKi: 8.11 (human H1R (hH1R)), 7.55 (human H4R (hH4R))), four known and 28 new oxazepine and related oxepine derivatives were synthesised and pharmacologically characterized at histamine receptors and selected aminergic GPCRs. In contrast to the oxazepine series, within the oxepine series, the new compounds showed high affinity to the hH1R (pKi: 6.8–8.7), but no or moderate affinity to the hH4R (pKi: ≤ 5.3). For one oxepine derivative (1-(2-Chloro-6,11-dihydrodibenzo[b,e]oxepin-11-yl)-4-methylpiperazine), the enantiomers were separated and the R-enantiomer was identified as the eutomer at the hH1R (pKi: 8.83 (R), 7.63 (S)) and the guinea-pig H1R (gpH1R) (pKi: 8.82 (R), 7.41 (S)). Molecular dynamic studies suggest that the tricyclic core of the compounds is bound in a similar mode into the binding pocket, as described for doxepine in the hH1R crystal structure. Moreover, docking studies of all oxepine derivatives at the hH1R indicate that the oxygen and the position of the chlorine in the tricyclic core determines, if the R- or the S-enantiomer is the eutomer. For some of the oxazepines and oxepines the affinity to other aminergic GPCRs is in the same range as to hH1R or hH4R, thus, those compounds have to be classified as dirty drugs. However, one oxazepine derivative (3,7-Dichloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine was identified as dual hH1/h5-HT2A receptor ligand (pKi: 9.23 (hH1R), 8.74 (h5-HT2AR), ≤7 at other analysed GPCRs), whereas one oxepine derivative (1-(3,8-Dichloro-6,11-dihydrodibenzo[b,e]oxepin-11-yl)-4-methylpiperazine) was identified as selective hH1R antagonist (pKi: 8.44 (hH1R), ≤6.7 at other analyzed GPCRs). Thus, the pharmacological results suggest that the oxazepine/oxepine moiety and additionally the chlorine substitution pattern toggles receptor selectivity and specificity.