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21733-94-8

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21733-94-8 Usage

General Description

2-(PhenoxyMethyl)benzoyl chloride 97 is a chemical compound that is primarily used as an intermediate in the pharmaceutical industry. It is a benzoyl chloride derivative with a phenoxyethyl group attached to the benzene ring, and it has a purity of 97%. 2-(PHENOXYMETHYL)BENZOYL CHLORIDE 97 is commonly utilized in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is known for its reactivity and ability to undergo a variety of chemical reactions, making it a versatile building block in organic synthesis. Additionally, it is important to handle 2-(phenoxyMethyl)benzoyl chloride 97 with caution as it is a corrosive and toxic substance that may cause irritation to the skin, eyes, and respiratory tract upon contact.

Check Digit Verification of cas no

The CAS Registry Mumber 21733-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,3 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 21733-94:
(7*2)+(6*1)+(5*7)+(4*3)+(3*3)+(2*9)+(1*4)=98
98 % 10 = 8
So 21733-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H11ClO2/c15-14(16)13-9-5-4-6-11(13)10-17-12-7-2-1-3-8-12/h1-9H,10H2

21733-94-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Phenoxymethyl)benzoyl chloride

1.2 Other means of identification

Product number -
Other names 2-phenoxymethylbenzoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21733-94-8 SDS

21733-94-8Relevant articles and documents

Synthesis, characterization, and biologic activity of new acyl hydrazides and 1,3,4-oxadiazole derivatives

Bleotu, Coralia,Diaconu, Carmen Cristina,Hanganu, Anamaria,Ionita, Petre,Limban, Carmen,Matei, Lilia,Nemes, Roxana Maria,Nicolau, Ioana,Nuta, Diana Camelia,P?un, Anca,Radulescu, Cristiana,Tatibou?t, Arnaud,Zarafu, Irina

, (2020/08/28)

Starting from isoniazid and carboxylic acids as precursors, thirteen new hydrazides and 1,3,4-oxadiazoles of 2-(4-substituted-phenoxymethyl)-benzoic acids were synthesized and characterized by appropriate means. Their biological properties were evaluated in terms of apoptosis, cell cycle blocking, and drug metabolism gene expression on HCT-8 and HT-29 cell lines. In vitro antimicrobial tests were performed by the microplate Alamar Blue assay for the anti-mycobacterial activities and an adapted agar disk diffusion technique for other non-tubercular bacterial strains. The best antibacterial activity (anti-Mycobacterium tuberculosis effects) was proved by 9. Compounds 7, 8, and 9 determined blocking of G1 phase. Compound 7 proved to be toxic, inducing apoptosis in 54percent of cells after 72 h, an effect that can be predicted by the increased expression of mRNA caspases 3 and 7 after 24 h. The influence of compounds on gene expression of enzymes implicated in drug metabolism indicates that synthesized compounds could be metabolized via other pathways than NAT2, spanning adverse effects of isoniazid. Compound 9 had the best antibacterial activity, being used as a disinfectant agent. Compounds 7, 8, and 9, seemed to have antitumor potential. Further studies on the action mechanism of these compounds on the cell cycle may bring new information regarding their biological activity.

Reactions of carbene intermediates from the reaction of trialkyl phosphites with dialkyl benzoylphosphonates: Intramolecular cyclisations of 2-substituted dialkyl benzoylphosphonates

Griffiths, D. Vaughan,Griffiths, Penelope A.,Karim, Khalku,Whitehead, Belinda J.

, p. 555 - 561 (2007/10/03)

The reaction of dialkyl benzoylphosphonates 1 with trialkyl phosphites leads to the formation of carbene intermediates 3 via the anionic intermediates 2. The carbene intermediates 3 (R = 2-PhO, 2-PhOCH2, and 2-PhS) have been generated by heating the corresponding 2-substituted dialkyl benzoylphosphonates with trimethyl phosphite and their subsequent reactions investigated. Reactions proceed either by intermolecular trapping of the carbene intermediates by trimethyl phosphite to give novel ylidic phosphonates 4, or by intramolecular routes involving carbene insertion into the π-system of the phenyl ring in the substituent. Studies using methyl-substituted derivatives have shown that the formation of the thioxanthenylphosphonate 15 (X = S, R′ = R″ = Me) proceeds via a spiro diene intermediate 14 (X = S, R′ = R″ = Me).

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