27684-87-3Relevant academic research and scientific papers
PqsR INVERSE AGONISTS
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Page/Page column 87; 88, (2020/01/31)
The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
Intramolecular Cyclization of Aryloxenium Ions. C-O-C and C-C Bond Formation. A Novel Ortho Effect
Abramovitch, Rudolph A.,Bartnik, Romuald,Cooper, Melanie,Dassanayake, Nissanke L.,Hwang, Hang-Yuong,et al.
, p. 4817 - 4818 (2007/10/02)
o-Aryloxenium ions undergo intramolecular C-O-C bond formation readily as shown by the cyclizations yielding dibenzofurans. m-Aryloxenium ions cyclize via C-C bond formation provided the molecule can adopt the appropriate conformation for ring closure to occur.When an oxygen atom is ortho to the ?-aryl cation center, cyclization to form five- or six-membered rings does not occur and this is attributed to an interaction between oxygen and the positive charge that imposes an unfavorible conformation for cyclization on the aryloxy or arylalkyloxy side chain.
