27686-50-6

Usage

Uses

Used in Biomedical Applications:
TRT-CYS(TRT)-OH is used as a building block for the synthesis of protein dendrimers, which are highly branched, nanoscale structures with potential applications in various fields, including drug delivery, diagnostics, and therapeutics. The trityl-protected cysteine derivative contributes to the structural integrity and functionality of these dendrimers, enhancing their performance in biomedical applications.
Used in Pharmaceutical Research:
As an inhibitor of human mitotic kinesin, TRT-CYS(TRT)-OH is employed in the development of drugs targeting cell division and proliferation. This makes it a valuable tool in the research and development of therapeutics for various diseases, including cancer, where the inhibition of cell division is a critical aspect of treatment.
Used in Chemical Synthesis:
TRT-CYS(TRT)-OH is also used as a key component in the synthesis of various chemical compounds, particularly those involving the modification or protection of cysteine residues. Its trityl group provides a stable and easily removable protecting group, facilitating the synthesis of complex molecules with specific properties and functions.

Upstream product

• 76-83-5 trityl chloride 
• 52-89-1 l-cysteine hydrochloride 
• 2799-07-7 S-trityl-L-cysteine 
• 52-90-4 L-Cysteine 

Downstream Products

• 31945-78-5 (S)-2-[(R)-2-(Trityl-amino)-3-tritylsulfanyl-propionylamino]-succinamic acid tert-butyl ester 
• 27560-18-5 NS-ditritylcysteine N-hydroxysuccinimide ester 
• 76587-61-6 S-(triphenylmethyl)-L-cysteine tert-butyl ester 
• 79385-62-9 Bpoc-Ser(Bu^t)-Cys(Trt)-OBu^t 
• 79385-61-8 O-t-butylseryl-S-tritylcysteine t-butyl ester hydrochloride 
• 90303-76-7 Z-Gln-Asn-Cys(Trt)-Pro-Arg(Mbs)-OtBu 
• 90303-74-5 C₄₄H₅₄N₆O₇S₂ 
• 111061-60-0 Trt-L-Cys(Trt)-OBt 
• 97014-22-7 N_.S-Ditrityl-L-cysteinylglycin-p-nitrophenylester 
• 13173-96-1 (S-trityl-L-cysteinyl)-glycine ethyl ester; hydrochloride 
• 26988-61-4 (S-trityl-L-cysteinyl)-glycine 
• 90303-71-2 Trt-Cys(Trt)-Pro-Arg(Mbs)-OtBu 
• 116505-37-4 N,S-Ditrityl-cysteyl-prolyl-arginyl-glycylamide 
• 79385-60-7 NS-ditritylcysteine t-butyl ester 

Relevant academic research and scientific papers

Preparation of N-Tritylamino Acids from N-Trimethylsilylamino Acid Trimethylsilyl Esters

Persilylated amino acids are used to prepare Nα-tritylamino acids 2,4, and 6 in high yields by cleavage of the Si-N bond with trityl chloride in chloroform under reflux.The side chains of Lys, Orn and Cys are simultaneously tritylated while sil

Application of the Trt and Fmoc Groups for the Protection of Polyfunctional α-Amino Acids

Simple methods for the preparation of ditrityl amino acids 3 and their application for the synthesis of the peptides 9-27 are described.Selective detritylation of 3 and of the synthesized ditrityl peptides is achieved with 1percent trifluoroacetic acid in dichloromethane.The resulting Nα-detritylated amino acids 5 were converted into the corresponding fluorenylmethoxycarbonyl amino acids 6 under Schotten-Baumann conditions using fluorenylmethyl chloroformate.