276872-83-4

Usage

Uses

Used in Medicinal Chemistry:
(+/-)-2-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-piperidine is used as a potentially psychoactive compound for its potential pharmacological effects on the central nervous system. Its structural similarity to other psychoactive drugs suggests that it may have applications in the development of new medications or therapies for various conditions related to the central nervous system. Further research is needed to explore its exact properties and potential uses in this field.

Upstream product

• 3433-37-2 piperidin-2-ylmethanol 
• 157634-00-9 tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate 
• 157634-02-1 tert-butyl 2-formylpiperidine-1-carboxylate 
• 276872-82-3 (+/-)-N-(t-butoxycarbonyl)-2-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-piperidine 

Relevant academic research and scientific papers

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.

CCR3 antagonist leads with IC(50) values in the microM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil chemotaxis induced by human eotaxin. In particular, 4-benzylpiperidin-1-yl-n-propylureas and erythro-3-(4-benzyl-2-(alpha-hydroxyalkyl)piperidin-1-yl)-n-propylureas (obtained via Beak reaction of N-BOC-4-benzylpiperidine) exhibited single digit nanomolar IC(50) values for CCR3.

Heterocycyclic piperidines as modulators of chemokine receptor activity

The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.