157634-00-9

Usage

Uses

Used in Pharmaceutical Industry:
N-Boc-piperidine-2-methanol is used as a key intermediate for the synthesis of various heterocyclic compounds and bioactive molecules. Its application is primarily due to its ability to be easily incorporated into complex molecular structures, enhancing the development of new drugs and therapeutic agents.
Used in Synthesis of Corydendramine:
N-Boc-piperidine-2-methanol is used as a reactant in the Julia coupling for the synthesis of corydendramine, a naturally occurring alkaloid with potential biological activities.
Used in Synthesis of Nitrogen-Containing Dienes:
N-Boc-piperidine-2-methanol is used as a reactant for the cyclization-functionalization of nitrogen-containing dienes, which are important intermediates in the development of novel pharmaceuticals and chemical compounds.
Used in Synthesis of Anthranilamide Inhibitors of Factor Xa:
N-Boc-piperidine-2-methanol is used as a reactant in the synthesis of anthranilamide inhibitors of factor Xa, which are potential anticoagulant agents.
Used in Synthesis of Human GnRH Receptor Antagonists:
N-Boc-piperidine-2-methanol is used as a reactant in the synthesis of human gonadotropin-releasing hormone (GnRH) receptor antagonists, which have applications in the treatment of various hormone-related disorders.
Used in Synthesis of Sphingosine-1-Phosphate Receptor Agonists:
N-Boc-piperidine-2-methanol is used as a reactant in the synthesis of sphingosine-1-phosphate (S1P) receptor agonists, which have potential applications in the treatment of immune and inflammatory disorders.

InChI:InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(12)8-13/h9,13H,4-8H2,1-3H3

Upstream product

• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3433-37-2 piperidin-2-ylmethanol 
• 132910-79-3 (+/-) methyl N-tert-butyloxycarbonyl 2-piperidinecarboxylate 
• 13139-12-3 tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate 
• 541-16-2 t-butyl malonate 
• 4043-87-2 pipecolic Acid 

Downstream Products

• 157634-02-1 tert-butyl 2-formylpiperidine-1-carboxylate 
• 134441-93-3 tert-butyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 948916-95-8 C₂₃H₃₅NO₅ 
• 948916-96-9 C₂₂H₃₃NO₅ 
• 948916-93-6 C₃₄H₄₁ClN₄O₅ 
• 193086-00-9 ((1-(tert-butoxycarbonyl)piperidin-2-yl)methoxy)acetic acid 
• 193086-01-0 2-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methoxymethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 2740-00-3 indolizidin-3-one 
• 179685-66-6 hexahydro-indolizine-3-thione 
• 1217-18-1 9-benzoyl-9-azabicyclo[3.3.1]nonan-2-one 
• 470669-28-4 9-benzoyl-2-methylene-9-azabicyclo[3.3.1]nonane 
• 470669-26-2 9-benzoyl-4-(trimethylsilylmethylene)-9-azabicyclo[3.3.1]nonane 
• 470669-24-0 (2-iodo-phenyl)-[2-(4-trimethylsilanyl-but-3-ynyl)-piperidin-1-yl]-methanone 
• 276872-83-4 (+/-)-2-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-piperidine 

Relevant academic research and scientific papers

Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

Specialized cellular networks of oxidoreductases coordinate the dithiol/disulfide-exchange reactions that control metabolism, protein regulation, and redox homeostasis. For probes to be selective for redox enzymes and effector proteins (nM to μM concentrations), they must also be able to resist non-specific triggering by the ca. 50 mM background of non-catalytic cellular monothiols. However, no such selective reduction-sensing systems have yet been established. Here, we used rational structural design to independently vary thermodynamic and kinetic aspects of disulfide stability, creating a series of unusual disulfide reduction trigger units designed for stability to monothiols. We integrated the motifs into modular series of fluorogenic probes that release and activate an arbitrary chemical cargo upon reduction, and compared their performance to that of the literature-known disulfides. The probes were comprehensively screened for biological stability and selectivity against a range of redox effector proteins and enzymes. This design process delivered the first disulfide probes with excellent stability to monothiols yet high selectivity for the key redox-Active protein effector, thioredoxin. We anticipate that further applications of these novel disulfide triggers will deliver unique probes targeting cellular thioredoxins. We also anticipate that further tuning following this design paradigm will enable redox probes for other important dithiol-manifold redox proteins, that will be useful in revealing the hitherto hidden dynamics of endogenous cellular redox systems.

Compound and preparation method and application thereof

The invention discloses a compound as well as a preparation method and application thereof, and the structural formula of the compound is as shown in formula 1. The research finds that the compound provided by the invention can be applied to preparation o

Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist

The discovery of a novel 3H-pyrido[2,3-d]pyrimidin-4-one series as potent and biased sst2 agonists is described. This class of molecules exhibits excellent sst2 potency and selectivity against sst1, sst3, and sst5 receptors, and they are significantly more potent at inhibiting cAMP production than inducing internalization. The orally bioavailable 6-(3-chloro-5-methylphenyl)-3-(3-fluoro-5-hydroxyphenyl)-5-({methyl[(2S)-pyrrolidin-2-ylmethyl]amino}methyl)-3H,4H-pyrido[2,3-d]pyrimidin-4-one (36) also suppresses GH secretion in GHRH-challenged rats in a dose-dependent manner.

A One-Pot Iodo-Cyclization/Transition Metal-Catalyzed Cross-Coupling Sequence: Synthesis of Substituted Oxazolidin-2-ones from N-Boc-allylamines

A one-pot iodo-cyclization/transition metal-catalyzed cross-coupling sequence is reported to access various C5-functionalized oxazolidin-2-ones from unsaturated N-Boc-allylamines. Depending on the Grignard reagents used for the cross-coupling, e.g., aryl- or cyclopropylmagnesium bromide, a cobalt or copper catalyst has to be used to obtain the functionalized oxazolidin-2-ones in good yields.

Donor–Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp3)–C(sp3) Cleavage and Allylation/Alkenylation

The alkoxyl radical is an essential and prevalent reactive intermediate for chemical and biological studies. Here we report the first donor–acceptor complex-enabled alkoxyl radical generation under metal-free reaction conditions induced by visible light. Hantzsch ester forms the key donor–acceptor complex with N-alkoxyl derivatives, which is elucidated by a series of spectrometry and mechanistic experiments. Selective C(sp3)-C(sp3) bond cleavage and allylation/alkenylation is demonstrated for the first time using this photocatalyst-free approach with linear primary, secondary, and tertiary alkoxyl radicals.

SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

Benzimidazole-2-piperazine compound, its pharmaceutical composition and its preparation and use

The invention relates to a benzimidazole-2-piperazine derivative and a preparing method and application of the benzimidazole-2-piperazine derivative in medicine, in particular to a novel benzimidazole-2-piperazine derivative shown in the general formula (I), a preparing method of the derivative, a pharmaceutical composition containing the derivative and application of the derivative serving as a therapeutic agent, especially serving as a poly (ADP-ribose) polymerase (PARP) inhibitor. In the general formula (I), R refers to hydrogen or halogen, G refers to carbonyl or methylene, m is 1-2, n is 1-3, and Q refers to hydrogen or C1-C4 alkyl. When X is methylene and Y is NR1 or methylene, X is NR1; R1 refers to hydrogen, C1-C6 alkyl, benzyl, COR2 or SO2R2; R2 refers to the following groups which are not substituted or groups substituted by 1-3 substituent groups, including C1-C6 alkyl, C3-C8 naphthenic base, phenyl, benzyl, naphthyl and C5-C10 aromatic heterocycle base, heterocycle in the C5-C10 aromatic heterocycle base comprises 1-3 heteroatoms selected from N, O and S, and the substituent groups are selected from the following atoms or groups of C1-C6 alkyl, C1-C6 alkoxy, halogen, amidogen, nitryl, sulfydryl, hydroxyl, cyanogroup and trifluoromethyl. The general formula (I) is shown in the specification.

NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES

The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.

PROCESS FOR MAKING TRICYCLIC LACTAM COMPOUNDS

Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).

An expedient synthesis of oxazepino and oxazocino quinazolines

A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring clos