2769-21-3Relevant articles and documents
Only acridine derivative from Hantzsch-type one-pot three-component reactions
Muscia, Gisela C.,Buldain, Graciela Y.,Asis, Silvia E.
, p. 1529 - 1532 (2009)
A three-component Hantzsch-type condensation of different anilines with dimedone and benzaldehyde leads to the formation of a unique acridine derivative with an unusual breaking of a C-N bond. The reaction was also carried out employing rapid microwave or
Acridine-based thiosemicarbazones as novel inhibitors of mild steel corrosion in 1 M HCl: Synthesis, electrochemical, DFT and Monte Carlo simulation studies
Akpan, Ekemini D.,Isaac, Ibanga O.,Olasunkanmi, Lukman O.,Ebenso, Eno E.,Sherif, El-Sayed M.
, p. 29590 - 29599 (2019)
Electrochemical, surface morphology, density functional theory and Monte Carlo simulation methods were employed in investigating the effects of (2E,2′E)-2,2′-(3,3,6,6-tetramethyl-9-phenyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-diylidene)bis(N-phenylhydrazinecarbothioamide) (IAB-NP), (2E,2′E)-2,2′-(3,3,6,6-tetramethyl-9-phenyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-diylidene)bis(N-(2,4-difluorophenyl)hydrazinecarbothioamide)IAB-ND) and (2E,2′E)-2,2′-(3,3,6,6-tetramethyl-9-phenyl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-diylidene)bis(N-(2-fluorophenyl) hydrazinecarbothioamide) (IAB-NF) on mild steel corrosion in 1 M HCl solution. From the studies, compounds IAB-NP, IAB-ND and IAB-NF inhibit mild steel corrosion in the acid and the protection efficiencies were found to increase with the increase in concentration of each compound. At the optimum inhibitor concentration of 1.5 × 10-4 M, the inhibition efficiencies (%) of the compounds are in the order IAB-NF (90.48) > IAB-ND (87.48) > IAB-NP (85.28). Potentiodynamic polarization measurements revealed that all the compounds acted as mixed-type corrosion inhibitors. Experimental data for the adsorption of the studied molecules on a mild steel surface in 1 M HCl fitted into the Langmuir adsorption isotherm and the standard free energies of adsorption (ΔGoads) suggested both physisorption and chemisorption mechanisms. Scanning electron microscopy analyses confirmed the formation of a protective film on the mild steel surface by the inhibitor molecules, resulting in protection of the metal from corrosive electrolyte ions. The experimental findings were corroborated by both theoretical density functional theory and Monte Carlo simulation studies.
Reaction of 3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones with lithium aluminum hydride
Pyrko
, p. 1029 - 1031 (2003)
The corresponding 3,3,6,6,-tetramethyl-1,2,3,4,5,6,7,8-octahydroacridines have been obtained by the interaction of 3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione, its 9-Ph- and 9-p-MeOC6H4-substituted derivative
Stereodirected catalytic synthesis of perhydroacridines and their isologs from decahydroacridine-1,8-diones
Nikolaeva,Shchekotikhin
, p. 582 - 593 (2004)
The catalytic reduction of decahydroacridine-1,8-diones has been studied under hydrogen pressure in the presence of Raney nickel and with nascent hydrogen from alkaline treatment of nickel-aluminum alloy. Conditions have been developed for the stereodirec
Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method
Hosseininasab, Fatemeh Sadat,Memarian, Hamid Reza
, (2022/01/11)
Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared β-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.
USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst
Alponti, Leonardo H.R.,Picinini, Monize,Urquieta-Gonzalez, Ernesto A.,Corrêa, Arlene G.
, (2020/10/20)
The Hantzsch three-component reaction is the best-known multicomponent reaction, affording dihydropyridines which have been employed therapeutically and also as visible‐light photoredox catalysts. In this work we report the application of an ultra-stable
Incorporation of Keggin-based H3PW7Mo5O40into bentonite: synthesis, characterization and catalytic applications
Aher, Dipak S.,Khillare, Kiran R.,Shankarwar, Sunil G.
, p. 11244 - 11254 (2021/03/31)
The Keggin-based molybdo-substituted tungstophosphoric acid, H3[PW7Mo5O40]·12H2O, were synthesized and incorporated with a bentonite clay by using a wetness impregnation method. The catalysts were cha
Preparation, Antibacterial Activity, and Catalytic Application of Magnetic Graphene Oxide-Fucoidan in the Synthesis of 1,4-Dihydropyridines and Polyhydroquinolines
Amirnejat, Sara,Javanshir, Shahrzad,Nosrati, Aliakbar
, p. 1186 - 1196 (2021/12/31)
Polymer-coated magnetic nanoparticles are emerging as a useful tool for a variety of applications, including catalysis. In the present study, fucoidan-coated magnetic graphene oxide was synthesized using a natural sulfated polysaccharide. The prepared BaF
Ag/CuO/MCM-48 As a potential catalyst for the synthesis of symmetrical and unsymmetrical polyhydroquinolines
Bazdid-Vahdaty, Narges,Khalili, Behzad,Mamaghani, Manouchehr,Tavakoli, Fateme
, p. 5136 - 5141 (2021/07/13)
Ag/CuO/MCM-48 as a heterogeneous catalyst was efficiently employed in the synthesis of diversely substituted symmetrical and unsymmetrical polyhydroquinoline by a multi-component reaction of arylaldehyde, dimedone, ethyl cyanoacetate and ammonium acetate. This novel method is simple, environmentally friendly, rapid, uses a recyclable catalyst and produces the products in high to excellent yields (83-97%) and lower reaction times (17-35 min). The catalyst can be reused at least 10 times without any appreciable decrease in its catalytic activities.
Synthesis of 1,8-Dioxo-decahydroacridine Derivatives via Ru-Catalyzed Acceptorless Dehydrogenative Multicomponent Reaction
Biswas, Nandita,Srimani, Dipankar
, p. 9733 - 9743 (2021/07/20)
A Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed. This reaction offers a cost-effective and simple operational strategy to synthesize biologically active 1,8-dioxodecahydroacridine derivatives. The protocol provides a wide range of substrate scope and various functional groups are also well tolerated under the reaction condition. To shed light on the mechanistic and kinetic study, some controlled experiments and deuterium labeling experiments were executed. A time-dependent product distribution experiment is also presented and the reaction scale-up is performed to highlight the practical utility of this strategy.
