27704-96-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
METHYL 2-BROMO-3-METHOXYPROPIONATE is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a key component in the development of new drugs and pesticides, contributing to advancements in these fields.
Used in Perfume and Cosmetic Industries:
METHYL 2-BROMO-3-METHOXYPROPIONATE is used as a flavoring agent and fragrance in the production of perfumes and cosmetics. Its fruity odor adds a pleasant scent to these products, enhancing their appeal to consumers.
Used in Chemical Industry:
METHYL 2-BROMO-3-METHOXYPROPIONATE is a valuable chemical building block with various applications in the chemical industry. Its versatility allows it to be used in the synthesis of a wide range of compounds, contributing to the development of new materials and technologies.
However, it is important to handle METHYL 2-BROMO-3-METHOXYPROPIONATE with caution, as it is a hazardous material that can cause skin and eye irritation upon contact. Proper safety measures should be taken during its use to minimize potential risks.

InChI:InChI=1/C5H9BrO3/c1-8-3-4(6)5(7)9-2/h4H,3H2,1-2H3

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 1729-67-5 Methyl 2,3-dibromopropionate 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 4519-46-4 methyl 2-bromoacrylate 
• 28078-73-1 methyl hypobromite 
• 3674-13-3 2,3-dibromopropionic acid ethyl ester 

Downstream Products

• 65090-78-0 α-bromo-β-methoxypropanoic acid 
• 17642-18-1 (E)-α-bromocrotonate de methyle 
• 97962-00-0 cis bromo-1 methoxymethyl-2 dicarbomethoxy-1,2 cyclopropane 
• 876392-25-5 methyl-2-(4-tert-butylphenoxy)-2-propenoate 
• 58478-03-8 methyl 3-methoxy-2-phenoxypropanoate 
• 19794-53-7 3-methoxy-2-aminopropionic acid 

Relevant academic research and scientific papers

SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein L1 is an optionally substituted C1-6 alkylene group or the like, L2 is a single bond or the like, L3 is a single bond or the like, R1, R2, and R3 are each independently an optionally substituted C1-4 alkyl group or the like, R4 is a hydrogen atom or the like, and R5 is a hydrogen atom or the like.

Synthesis method of O-methyl-D-serine

The invention discloses a synthesis method of O-methyl-D-serine. The synthesis method includes the following steps that 1, acrylic acid methyl ester is added into a reaction bottle, after the temperature is raised, bromine is dropwise added, after an addition reaction is conducted, decompression and distillation are conducted to remove excessive bromine, methyl alcohol is added to residues, after the temperature is lowered, sodium methylate is added, after an alcoholysis reaction, decompression and distillation are conducted to remove methyl alcohol, ammonium hydroxide is added, after an ammonium hydroxide, concentrated crystallization is conducted, and O-methyl-DL-serine is obtained; 2, acetic acid is added into the reaction bottle, the O-methyl-DL-serine, D-tartaric acid and salicylaldehyde are added in sequence, after the temperature is raised for a reaction, cooling and crystallization are conducted, separation is conducted, and O-methyl-D-serine double salt is obtained; 3, the O-methyl-D-serine double salt is dissolved in a methyl alcohol aqueous solution, ammonium hydroxide is added to regulate PH to be 7-8, crystallization and separation are conducted, and the O-methyl-D-serine is obtained. The synthesis method is mild in reaction temperature, safe to operate, low in cost and high in chirality purity, and raw materials are easy to obtain.

NEW PROCESS

There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I : according to the methods defined in the application.

N-Substituted amino acid N′-benzylamides: Synthesis, anticonvulsant, and metabolic activities

Amino acid amides (AAA) were prepared and evaluated in seizure models. The AAA displayed moderate-to-excellent activity in the maximal electroshock seizure (MES) test and were devoid of activity in the subcutaneous Metrazol-induced (scMet) seizure test. The AAA anticonvulsant activity was neither strongly influenced by the C(2) substituent nor by the degree of terminal amine substitution. An in vitro metabolism study suggested that the structure-activity relationship pattern was due, in part, to metabolic processes that occurred at the N-terminal amine unit.

QUINOLIN-, ISOQUINOLIN-, AND QUINAZOLIN-OXYALKYLAMIDES AND THEIR USE AS FUNGICIDES

Fungicidal compounds of the general formula (1) wherein one of X and Y is N or N-oxide and the other is CR or both of X and Y are N.

N-ALKYNYL-2- (SUBSTITUTED PHENOXY) ALKYLAMIDES AND THEIR USE AS FUNGICIDES

Fungicidal compounds of the general formula (1) wherein X, Y, Z, R1, R2, R3, R4 and R5 have the definitions given in claim 1.

N-ALKYNYL-2-HETEROARYLOXYALKYLAMIDES FOR USE AS FUNGICIDES

Compounds of the general formula (I) are useful as fungicides wherein Het is a 5- or 6- linked group of the formula (a) or (b), and the variables are as defined in the claims.

Structure-Function Relationship of Acyl Amino Acid Surfactants: Surface Activity and Antimicrobial Properties

Amino acid surfactants (AAS), having the general structure α-amino-(N-acyl)-β-alkoxypropionate, were synthesized chemically.Surface activity and antimicrobial properties of the AAS were evaluated.Increases in acyl chain length (i.e., C10-C14) resulted in a linear reduction in surface tension (i.e., 43-36 mN*m-1), as well as dramatic decreases in critical micelle concentrations (cmc) (i.e., 17.9-0.43 mM).Strong correlations existed between the cmc of AAS and their minimal inhibitory concentrations (mic) against Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, and Saccharomyces cerevisiae.Sensitivity of the microorganisms to the various AAS followed the order Staphylococcus aureus > A. niger= S. cerevisiae> E. coli> P. aeruginosa.In comparison with methyl p-hydroxybenzoate, AAS (MN14) showed 2-8, 64, and 4-8 times the activity against Gram-negative bacteria, Gram-positive bacteria, and fungi, respectively.Surface adsorption and/or bifunctional binding to the cell membrane may account for AAS action on microorganisms.

AMINO ACIDS; 13. INVESTIGATIONS ON THE SYNTHESIS OF DL-SERINE FROM α-HALOACRYLIC ACID DERIVATIVES

The alkoxide-catalyzed addition of alcohols 2 to α-chloroacrylonitrile (1) at -35 degC gives rise to 3-alkoxy-2-chloropropanenitriles 3; at 0-5 degC with excess 2 alkyl 3-alkoxy-2-chloropropanimidates 4 are obtained.The yields of 3 or 4 decrease with increasing pKa values of the alcohols 2.In the basecatalyzed addition of phenols 5 to 1, a temperature-dependent addition equilibrium is set up in which the position of equilibrium is shifted in favour of the addition products 6 with increasing pKa values of 5.The 3-alkoxy-2-chloropropanoates 8, which are readily accessible by hydrolysis of 4, react smoothly with sodium azide in the presence of a phase transfer catalyst to furnish the 3-alkoxy-2-azidopropanoates 10.Starting from benzyl 2-azido-3-benzyloxy-propanoate (10b), the specific syntheses of DL-serine (14), DL-serine hydrochloride (14*HCl), DL-serine methyl ester hydrochloride (13a*HCl), O-benzyl-DL-serine (12b), and O-benzyl-DL-serine benzyl ester hydrochloride (11b*HCl) are possible by variation of the hydrogenation conditions.

Reactions de cyclopropanation par double addition de Michael.

The addition of nucleophiles to alkyl α bromoacrylates in aprotic media leads to the stereospecific formation of cylopropanes by a double Michael addition reaction.