2772-45-4

Basic information

• Product Name: 2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL
• Synonyms: 2,4-Bis(;2,4-Bis(alpha,alpha-dimethylbenzyl)phenol 95%;2,4-bis(1-methyl-1-phenylethyl)-pheno;2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL;2,4-DI-ALPHA-CUMYLPHENOL;2,4 DI-CUMYLPHENOL;2,4-bis(1-methyl-1-phenylethyl)phenol;Phenol, 2,4-bis(1-methyl-1-phenylethyl)-
• CAS NO: 2772-45-4
• Molecular Formula: C₂₄H₂₆O
• Molecular Weight: 330.46
• EINECS: 220-466-0
• Product Categories: Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 2772-45-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 63-65 °C(lit.)
• Boiling Point: 206 °C15 mm Hg(lit.)
• Flash Point: 204.9 °C
• Appearance: /
• Density: 1.063
• Vapor Pressure: 2.15E-08mmHg at 25°C
• Refractive Index: 1.6380 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 10.71±0.10(Predicted)
• CAS DataBase Reference: 2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL(2772-45-4)
• EPA Substance Registry System: 2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL(2772-45-4)

Safety Data

• Hazard Codes: Xi
• Statements: 26-27-36/39-36
• Safety Statements: 26-27-28-36/39
• WGK Germany: 3
• Hazardous Substances Data: 2772-45-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2772-45-4 differently. You can refer to the following data:
1. UV Stabilizer and Antioxidant Intermediate
2. 2,4-bis(2-Phenylpropan-2-yl)phenol is used as a reagent in ring opening polymerization reactions of cyclic esters. It is an intermediate in the synthesis of Benzotriazole BT (B206990), a low volatile benzotriazole UV light absorber and stabilizer.
3. 2,4-Bis(α,α-dimethylbenzyl)phenol may be used in the preparation of a novel ligand, 2,2′-methylenebis(4,6-di(1-methyl-1-phenylethyl)phenol) (MMPEP-H2).

General Description

2,4-Bis(α,α-dimethylbenzyl)phenol is reported to possess antihistaminic activity. Structure of 2,4-bis(α,α-dimethylbenzyl)phenol is reported to have a torsion angle of 129.95(13)° for the C-C bond that connects the benzyl carbon to the phenol ring ortho to the OH group.

InChI:InChI=1/C24H26O/c1-23(2,18-11-7-5-8-12-18)20-15-16-22(25)21(17-20)24(3,4)19-13-9-6-10-14-19/h5-17,25H,1-4H3

Upstream product

• 98-83-9 isopropenylbenzene 
• 108-95-2 phenol 
• 599-64-4 p-cumylphenol 

Downstream Products

• 921201-48-1 2,2'-dithiobis[4,6-di-(2-phenyl-2-propyl)phenol] 
• 918424-28-9 C₄₈H₅₀O₄S 
• 108-95-2 phenol 
• 70693-50-4 2-Nitro-2'-hydroxy-3',5'-di(α,α-dimethylbenzyl)azobenzene Acid 
• 1227408-24-3 2-(N-(3-tert-butyl-2-methoxy-5-methylbenzyl)-N-[2-(N,N-dimethyl)aminoethyl]aminomethyl)-4,6-dicumylphenol 
• 1227408-28-7 2-(N-(2-(N,N-dimethylamino)-5-methylbenzyl)-N-[2-(N,N-dimethyl)aminoethyl]aminomethyl)-4,6-dicumylphenol 
• 1227408-26-5 2-(N-(2-methoxybenzyl)-N-[2-(N,N-dimethyl)aminoethyl]aminomethyl)-4,6-dicumylphenol 
• 1267647-88-0 N,N'-(4,4'-methanediyl-diphenyl)-di(carbamic acid (2,4-dicumylphenyl) ester) 
• 451456-80-7 (S)-2-[N-{3,5-bis(α,α-dimethylbenzyl)salicylidene}amino]-3,3-dimethyl-1-butanol 
• 356763-82-1 2-hydroxy-3,5-dicumylbenzaldehyde 

Relevant articles and documents

Ortho-aminophenol Schiff base, and synthesis method and application thereof

The invention discloses an ortho-aminophenol Schiff base, and a synthesis method and application thereof, and relates to an ortho-aminophenol Schiff base compound, and a synthesis method and application thereof. The invention aims to solve the problem of poor organic phase solubility of a conventional salicylaldehyde ortho-aminophenol Schiff base zinc complex. The invention relates to a structural formula of an ortho-aminophenol Schiff base fluorescent probe compound. The synthesis method comprises: 1, FriedelCrafts alkylation; 2, formylation reaction; 3, condensation reaction. The ortho-aminophenol Schiff base serving as a fluorescent probe is applied to qualitative and quantitative analysis for a trace metal ion Zn2+. After a lipophilic group is introduced to a benzene ring of salicylaldehyde, the condensation reaction with ortho-aminophenol is performed to generate the ortho-aminophenol Schiff base, and a complex generated by coordination between the ortho-aminophenol Schiff base and a zinc ion presents good solubility in an organic phase, and a fluorescence detection signal is obviously enhanced. The invention can be applied to the field of fluorescent probes.

Amino-acid schiff base, and synthesis method and application thereof

The invention discloses an amino-acid schiff base, and a synthesis method and an application thereof, relates to an amino-acid schiff base compound and a synthesis method and application thereof and mainly aims at solving the problem of poor organic phase solubility of an existing salicylaldehyde-amino acid schiff base compound. The invention relates to a structural formula of an amino-acid schiff base fluorescent probe compound. The synthesis method comprises the steps of (1) FriedelCrafts alkylation reaction; (2) formylation reaction; and (3) condensation reaction. The invention further discloses an application of the amino-acid schiff base in qualitative and quantitative analysis of trace metal ions Zn as a fluorescent probe. A hydrophobic group is introduced into a benzene ring of salicylaldehyde and is subjected to condensation reaction with amino acid to generate the amino-acid schiff base, and a complex generated through coordination of the amino-acid schiff base and zinc ions has good solubility in an organic phase and a fluorescent detection signal is obviously strengthened. The amino-acid schiff base can be applied to the field of the fluorescent probe.

Synthesis of salicylaldehydes bearing bulky substituents in the positions 3 and 5

Reaction of 2,4-disubstituted phenols with paraformaldehyde in the presence of SnCl4 and 2,6-lutidine afforded a number of new salicylaldehydes, containing bulky substituents (tert-butyl, 1-phenylethyl, 1-(4-tert- butylphenyl)ethyl, α-cumyl, and trityl) in the positions 3 and 5.