2772-45-4

Usage

Uses

Used in Chemical Synthesis:
2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL is used as an intermediate in the synthesis of various compounds, including Benzotriazole BT (B206990), a low volatile benzotriazole UV light absorber and stabilizer. It is also used as a reagent in ring-opening polymerization reactions of cyclic esters.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL is used as a starting material for the preparation of novel ligands, such as 2,2′-methylenebis(4,6-di(1-methyl-1-phenylethyl)phenol) (MMPEP-H2), which can be utilized in the development of new drugs and therapeutic agents.
Used in Plastics and Coatings Industry:
2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL is used as a UV stabilizer and antioxidant intermediate in the plastics and coatings industry. Its incorporation into these materials helps to prevent degradation caused by exposure to sunlight and other sources of UV radiation, thereby extending the lifespan and maintaining the appearance of the products.
Used in Research and Development:
Due to its unique structure and properties, 2,4-BIS(ALPHA,ALPHA-DIMETHYLBENZYL)PHENOL is also used in research and development for the exploration of new applications and potential improvements in existing technologies. This includes its antihistaminic activity, which may lead to the development of new medications for the treatment of allergies and other related conditions.

InChI:InChI=1/C24H26O/c1-23(2,18-11-7-5-8-12-18)20-15-16-22(25)21(17-20)24(3,4)19-13-9-6-10-14-19/h5-17,25H,1-4H3

Upstream product

• 98-83-9 isopropenylbenzene 
• 108-95-2 phenol 
• 599-64-4 p-cumylphenol 

Downstream Products

• 356763-82-1 2-hydroxy-3,5-dicumylbenzaldehyde 
• 70693-50-4 2-Nitro-2'-hydroxy-3',5'-di(α,α-dimethylbenzyl)azobenzene Acid 
• 451456-80-7 (S)-2-[N-{3,5-bis(α,α-dimethylbenzyl)salicylidene}amino]-3,3-dimethyl-1-butanol 
• 1309072-86-3 4,6-dicumyl-2-(N-(2-methoxybenzyl)-N-[2-(N',N'-diethylamino)ethyl]aminomethyl)-phenol 
• 1309072-91-0 4,6-dicumyl-2-(N-(3-tert-butyl-2-methoxy-5-methylbenzyl)-N-[3-(N',N'-dimethylamino)propyl]aminomethyl)-phenol 
• 1309072-90-9 4,6-dicumyl-2-(N-(2-methoxybenzyl)-N-[3-(N',N'-dimethylamino)propyl]aminomethyl)-phenol 
• 1309072-88-5 4,6-dicumyl-2-(N-(3-tert-butyl-2-methoxy-5-methylbenzyl)-N-[2-(N',N'-diethylamino)ethyl]aminomethyl)-phenol 
• 1267647-88-0 N,N'-(4,4'-methanediyl-diphenyl)-di(carbamic acid (2,4-dicumylphenyl) ester) 
• 1227408-26-5 2-(N-(2-methoxybenzyl)-N-[2-(N,N-dimethyl)aminoethyl]aminomethyl)-4,6-dicumylphenol 
• 1227408-28-7 2-(N-(2-(N,N-dimethylamino)-5-methylbenzyl)-N-[2-(N,N-dimethyl)aminoethyl]aminomethyl)-4,6-dicumylphenol 

Relevant academic research and scientific papers

Ortho-aminophenol Schiff base, and synthesis method and application thereof

The invention discloses an ortho-aminophenol Schiff base, and a synthesis method and application thereof, and relates to an ortho-aminophenol Schiff base compound, and a synthesis method and application thereof. The invention aims to solve the problem of poor organic phase solubility of a conventional salicylaldehyde ortho-aminophenol Schiff base zinc complex. The invention relates to a structural formula of an ortho-aminophenol Schiff base fluorescent probe compound. The synthesis method comprises: 1, FriedelCrafts alkylation; 2, formylation reaction; 3, condensation reaction. The ortho-aminophenol Schiff base serving as a fluorescent probe is applied to qualitative and quantitative analysis for a trace metal ion Zn2+. After a lipophilic group is introduced to a benzene ring of salicylaldehyde, the condensation reaction with ortho-aminophenol is performed to generate the ortho-aminophenol Schiff base, and a complex generated by coordination between the ortho-aminophenol Schiff base and a zinc ion presents good solubility in an organic phase, and a fluorescence detection signal is obviously enhanced. The invention can be applied to the field of fluorescent probes.

METHOD FOR MANUFACTURING α-METHYLSTYRENATED PHENOL

According to an embodiment of the present invention, the present invention provides a method for manufacturing α-methyl styrenated phenol, which comprises the following steps: (a) making phenol react with α-methyl styrene (AMS) under the presence of a first acidic catalyst to obtain a first product; and (b) additionally making 1-5 equivalents of α-methyl styrene for 1 equivalent of phenol react with the first product under the presence of a second acidic catalyst to obtain a second product. The manufactured α-methyl styrenated phenol does not generate environmental damage and is economical.(a) Making phenol react with α-methyl styrene (AMS) under the presence of a first acidic catalyst(AA) Obtaining 30-50 wt% of TMPI, 1-10 wt% DMP, 5-20 wt% of cumyl phenol, 1-10 wt% of AMS trimer, and the remaining phenol(b) Additionally making the α-methyl styrene react with a first product under the presence of a second acidic catalyst(BB) Obtaining 5-50 wt% of TMPI + DMP, 2-20 wt% of cumyl phenol, 1-10 wt% of dicumene, 20-60 wt% of dicumyl phenol, and 0.1-5 wt% of AMS trimerCOPYRIGHT KIPO 2017

Amino-acid schiff base, and synthesis method and application thereof

The invention discloses an amino-acid schiff base, and a synthesis method and an application thereof, relates to an amino-acid schiff base compound and a synthesis method and application thereof and mainly aims at solving the problem of poor organic phase solubility of an existing salicylaldehyde-amino acid schiff base compound. The invention relates to a structural formula of an amino-acid schiff base fluorescent probe compound. The synthesis method comprises the steps of (1) FriedelCrafts alkylation reaction; (2) formylation reaction; and (3) condensation reaction. The invention further discloses an application of the amino-acid schiff base in qualitative and quantitative analysis of trace metal ions Zn as a fluorescent probe. A hydrophobic group is introduced into a benzene ring of salicylaldehyde and is subjected to condensation reaction with amino acid to generate the amino-acid schiff base, and a complex generated through coordination of the amino-acid schiff base and zinc ions has good solubility in an organic phase and a fluorescent detection signal is obviously strengthened. The amino-acid schiff base can be applied to the field of the fluorescent probe.

Rhenium-catalyzed regioselective alkylation of phenols

(Chemical Equation Presented) Treatment of phenol derivatives with terminal alkenes in the presence of a catalytic amount of a rhenium complex, Re 2(CO)10, gave monoalkylated phenol derivatives in good to excellent yields. This reaction proceeds at the ortho- or para-position of phenols regioselectively.

Synthesis of salicylaldehydes bearing bulky substituents in the positions 3 and 5

Reaction of 2,4-disubstituted phenols with paraformaldehyde in the presence of SnCl4 and 2,6-lutidine afforded a number of new salicylaldehydes, containing bulky substituents (tert-butyl, 1-phenylethyl, 1-(4-tert- butylphenyl)ethyl, α-cumyl, and trityl) in the positions 3 and 5.

4-higher alkyl-2-nitro-2'-hydroxy-3',5'-di-higher alkyl (or cumyl)-azobenzenes

4-Higher alkyl-2-nitro-2'-hydroxy-3',5'-di-higher alkyl (or cumyl)-azobenzenes are made by coupling the corresponding diazotized 4-higher alkyl-o-nitroaniline with the corresponding substituted phenol. These azobenzene intermediates are used to prepare the corresponding 2H-benzotriazole UV absorber stabilizers substituted on the 5-position of the benzo ring by a higher alkyl group, preferably tert-octyl or n-dodecyl.

5-aralkyl substituted 2H-benzotriazoles and stabilized compositions

5-alpha-Cumyl-2-(2-hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole and related 2H-benzotriazoles substituted on the benzo ring by at least one aralkyl group such as benzyl, alpha-methylbenzyl or alpha-cumyl exhibit outstanding efficacy in protecting organic substrates from light-induced deterioration as well as good resistance to loss by volatilization or exudation during the high temperature processing of stabilized compositions. The above-named compounds are surprisingly soluble in common organic solvents, and exhibit very high extinction coefficients.

High caustic coupling process for preparing substituted 2-nitro-2'-hydroxyazobenzenes

Substituted 2-nitro-2'-hydroxyazobenzenes are prepared by adding an aqueous mineral acid solution of a diazotized o-nitroaniline to a strongly alkaline lower alkanol or aqueous lower alkanol solution of a substituted phenol, containing sufficient alkali metal hydroxide to assure a pH value substantially over 11 and an excess of hydroxyl ion in the reaction mixture even after all the acidic diazonium salt solution is added, wherein the reaction solvent mixture is at least 50% by weight of lower alkanol, at a reaction temperature between -15° C. and +30° C. The o-nitroazobenzenes obtained are intermediate products useful in the manufacture of benzotriazole UV absorbers.

High caustic coupling process for preparing substituted 2-nitro-2'-hydroxyazobenzenes

Substituted 2-nitro-2'hydroxyazobenzenes are prepared by adding an aqueous mineral acid solution of a diazotized o-nitroaniline to a strongly alkaline lower alkanol or aqueous lower alkanol solution of a substituted phenol, containing sufficient alkali metal hydroxide to assure a pH value substantially over 11 and an excess of hydroxyl ion in the reaction mixture even after all the acidic diazonium salt solution is added, wherein the reaction solvent mixture is at least 50% by weight of lower alkanol, at a reaction temperature between -15° C. and +30° C. The o-nitroazobenzenes obtained are intermediate products useful in the manufacture of benzotriazole UV absorbers.