27764-00-7

Upstream product

• 14248-31-8 2-methyl-1-(p-tolyl)butan-1-ol 
• 111508-11-3 C₂₄H₂₄N₆ 
• 5856-79-1 iso-butyl chloroformate 
• 108-88-3 toluene 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 598-30-1 sec.-butyllithium 
• 15366-08-2 s-butylmagnesium chloride 
• 39248-93-6 4-methyl(thiobenzoic) acid S-(4-chlorophenyl) ester 
• 101749-61-5 tri-sec-butylindium 
• 66534-32-5 α,α-diisopropyl-β-methylhomoallylic alcohol 
• 104-87-0 4-methyl-benzaldehyde 
• 111098-80-7 bis(benzotriazolo)(4-methylphenyl)methane 
• 5395-43-7 tri(p-tolyl)antimony 

Relevant academic research and scientific papers

Highly efficient Pd-catalyzed carbonylative cross-coupling reactions with tetraorganoindates

Tetraorganoindates, which were prepared easily from the reaction of 1 equiv of InCl3 with 4 equiv of organometallics, could be employed as effective nucleophilic cross-coupling partners in Pd-catalyzed carbonylative cross-coupling reactions with a variety of organic electrophiles. The present method gave unsymmetrical ketones and 1,4-diacylbenzenes in good yields with highly efficient transfer of almost all the organic groups attached to the indium under a carbon monoxide atmosphere in THF at 60 °C.

Phenyl butanone derivative and its use as photoinitiators

The invention provides a novel compound 1-(4-methylphenyl)-2-ethyl-2-hydroxy-2-butanone and a preparation method thereof, and application of the compound as a photoinitiator. The invention also discloses a photopolymerizable composition using the compound as the photoinitiator and application thereof, and a coating substrate coated with the composition.

Rhodium-catalyzed allyl transfer from homoallyl alcohols to aldehydes via retro-allylation followed by isomerization into ketones

Retro-allylation of homoallyl alcohol by rhodium catalysis occurs to generate allylrhodium species. This allylrhodium reacts with aldehydes to give the corresponding secondary alcohols in situ. Isomerization of these alcohols proceeds in the same pots to furnish the corresponding saturated ketones in good yields.

Palladium-catalyzed coupling of thiol esters with aryl and primary and secondary alkyl organoindium reagents

Thiol esters and organoindium reagents undergo palladium-catalyzed cross-coupling under mild conditions to give ketones in moderate to excellent yields. Aryl and primary/ secondary alkyl organoindium reagents can be used as coupling partners. This method has two advantages over the cross-coupling of thiol esters with boron and tin reagents: (1) no added copper reagent is required to mediate the reaction and (2) for the case of alkyl transfer, no added base is required to activate organoindium reagents for cross-coupling as is required for the coupling of alkyl boron reagents with thiol esters.

Pd-catalyzed carbonylative cross-coupling reactions by triorganoindiums: Highly efficient transfer of organic groups attached to indium under atmospheric pressure

(Matrix presented) A highly atom-efficient synthetic method of unsymmetrical ketones was developed by using trialkyl- and triarylindiums, which could be employed as effective cross-coupling partners in Pd-catalyzed carbonylative cross-coupling reactions with a variety of organic electrophiles. The present method produced unsymmetrical ketones and 1,4-diacylbenzenes in good yields with highly efficient transfer of almost all the organic groups attached to the indium under atmospheric pressure of CO gas in THF at 66°C.

One-Pot Synthesis of α-Chloro Ketones from Secondary Alcohols Using N,N-Dichloro-p-toluenesulfonamide

Various alkyl aryl secondary alcohols reacted with N,N-dichloro-p-toluenesulfonamide (N,N-dichloroamine-T) in CH3CN at 35 deg C to give the corresponding α-chloro ketones in excellent yields under mild and neutral conditions.

The Chemistry of N-Substituted Benzotriazoles. Part 6. A New Synthetic Route to Aromatic Ketones

Lithiation of p-bis(benzotriazol-1-yl)methyltoluene (4) gives the carbanion (5) which affords substitution products with many electrophiles.Acidic hydrolysis of the lithiation products affords the corresponding aromatic ketones in good yield.The syntheses of simple ketones, of diketones, and of α-hydroxy ketones are described.

Kinetics and Mechanism of the Reaction of Ketones with Lithium Reagents in Cyclohexane

The kinetics of the reaction of sec-BuLi and n-BuLi with several substituted phenyl sec-butyl ketones in cyclohexane at 25.0 deg C have been examined by stopped-flow infrared spectroscopy.Experiments in which reacting solutions of the ketones were scanned