5395-43-7

Basic information

• Product Name: 1-({[5-(1-methylethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetyl)azepane
• CAS NO: 5395-43-7
• Molecular Formula: C₂₁H₂₁Sb
• Molecular Weight: 283.3897
• Mol File: 5395-43-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 450.9°C at 760 mmHg
• Flash Point: 226.5°C
• Density: 1.19g/cm³
• Vapor Pressure: 2.55E-08mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1-({[5-(1-methylethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetyl)azepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-({[5-(1-methylethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetyl)azepane(5395-43-7)
• EPA Substance Registry System: 1-({[5-(1-methylethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetyl)azepane(5395-43-7)

Safety Data

• Hazardous Substances Data: 5395-43-7(Hazardous Substances Data)

Usage

General Description

1-({[5-(1-methylethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetyl)azepane is a chemical compound with the molecular formula C13H22N4O2S. It belongs to the class of organic compounds known as azepanes, which are saturated seven-membered heterocycles containing a nitrogen atom. 1-({[5-(1-methylethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetyl)azepane contains an oxadiazole ring, which is a five-membered heterocyclic ring containing oxygen and nitrogen atoms. The presence of the thioether group in the molecule gives it potential biological and pharmaceutical activities. It is commonly used in medicinal chemistry and drug development for its potential as a therapeutic agent.

Upstream product

• 106-38-7 para-bromotoluene 
• 2417-95-0 p-tolyllithium 
• 10025-91-9 antimony(III) chloride 
• 84786-43-6 tri(p-tolyl)phenylstibonium iodide 
• 158502-88-6 p-tolylbis(trimethylsilyl)antimony 
• 84790-21-6 tri(p-tolyl)phenylstibonium tetrafluoroborate 
• 84786-45-8 tri(p-tolyl)phenylantimony p-methoxyphenylmercaptide 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 7789-61-9 antimony(III) bromide 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 2417-95-0 p-tolyllithium 
• 50390-51-7 4'-methylisobutyrophenone 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 451-25-2 4-(4-methylphenyl)pentan-2-one 
• 16251-78-8 3-(p-tolyl)-butyraldehyde 
• 54881-85-5 1,2-di-4-methylphenylethanol 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 
• 63288-16-4 PtCl₂{Sb(CH₃C₆H₄)3}2 
• 69053-12-9 (CH₃C₆H₄)3SbIBr 
• 60043-16-5 tri(p-tolyl)antimony dibromide 
• 460752-07-2 (CH₃C₆H₄)3Sb(OCOC₆H₂F₃)2 
• 460752-05-0 (CH₃C₆H₄)3Sb(OCOC₆F₅)2 
• 78989-74-9 O-tri(p-methylphenyl)antimony(V) bis(diphenyloximate) 

Relevant articles and documents

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity

We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n- [X = PV (1-P), AsV (1-As), or GeIV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).

Two-step synthesis of triarylmetals (As, Sb, Bi) starting from the metal oxides and 2,6-dimethoxybenzenethiol

Reported here is a new synthetic method of triarylmetals MAr3 (M = As, Sb, Bi). It is composed of two-step reactions starting from the metal oxides: (1) A reaction of the metal oxide with 2,6-dimethoxybenzenethiol ΦSH [Φ = 2,6-(MeO)2C6H3] in the presence of acid to give the thiolatometals M(SΦ)3, and (2) A reaction of M(SΦ)3 with organolithium reagent LiAr to give MAr3 (Ar = Ph, 4-MeC6H4, 4-Me2NC6H4, Φ). Since ΦSH is odorless and crystalline, most of it can be recovered after the reactions without difficulty for repeated usages. The intermediates M(SΦ)3 are also crystalline and inert against hydrolysis.

Syntheses, Structures, and Equilibria of o-, m-, p-Tolyl- and Phenylantimony Rings

Exchange reactions of R3Sb (R = o-Tol, m-Tol, p-Tol) with SbCl3 in a 1:2 molar ratio give RSbCl2.Silylstibanes RSb(SiMe3)2 were obtained by reaction of RSbCl2 and Me3SiCl with Mg in THF.Slow access of air to solutions of RSb(SiMe3)2 afforded orange crystals of the composition (RSb)n.Crystal structures were determined by X-ray crystallography fro R = o-Tol and m-Tol as stacks of (RSb)6 rings in the chair conformation with equatorial substituents.In the crystals of (m-TolSb)6 there are short intermolecular Sb***Sb distances of 420 pm.Solutions of (RSb)n (R = Ph, o-Tol, m-Tol, p-Tol) in C6D6 were analyzed by 1H-NMR spectroscopy.They contain (RSb)5 and (RSb)4 in equilibria.Raman spectra of (PhSb)6 or (p-TolSb)n show signals for Sbn at = 151 or 153 cm-1. 13C-CP-MAS-NMR data of (p-TolSb)n are reported. - Key Words: Cyclopentastibanes/ Cyclohexastibanes/ Antimony compounds/ Phenylantimony rings