2778-34-9

Usage

Uses

Used in Pharmaceutical Industry:
Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, ethyl ester is used as a building block for the synthesis of peptides and proteins, which are essential components of many pharmaceutical products. Its ability to form stable bonds with other amino acids makes it a valuable component in the development of new drugs and therapeutic agents.
Used in Drug Delivery Systems:
Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, ethyl ester is used as a component in drug delivery systems to improve the efficiency and effectiveness of drug administration. Its ability to form stable bonds with other molecules allows for the development of targeted drug delivery systems, which can enhance the therapeutic effects of drugs and reduce side effects.
Used in Research and Laboratory Settings:
Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, ethyl ester is used as a reagent and intermediate in organic synthesis, particularly in the synthesis of complex organic compounds and pharmaceuticals. Its versatility and reactivity make it a valuable tool in research and development efforts.
Used in Organic Synthesis:
Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, ethyl ester is used as a reagent in various organic synthesis processes, including the formation of esters, amides, and other functional groups. Its ability to participate in a wide range of chemical reactions makes it a useful building block in the synthesis of complex organic compounds.
It is important to handle Glycine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, ethyl ester with care and follow proper safety precautions due to its potential hazards.

Upstream product

• 1641-40-3 pyrocatechol phosphorochloridite 
• 1161-13-3 N-Cbz-L-Phe 
• 459-73-4 GlyOEt*HCl 
• 927-80-0 1-ethoxyacetylene 
• 589-57-1 diethyl phosphorylchloridite 
• 1498-42-6 phosphorodichloridous acid ethyl ester 
• 54722-81-5 1-chloro-1-ethoxy-ethene 
• 543-27-1 isobutyl chloroformate 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 
• 623-33-6 glycine ethyl ester hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 75509-45-4 N-(2-oxido-1,2,3-benzodioxaphosphol-2-yl) glycine ethyl ester 
• 87072-42-2 Z-L-phenylalanine DCHA salt 
• 26055-07-2 Z-Phe-OBT 

Downstream Products

• 75501-72-3 N-[N-(benzyloxycarbonyl-glycyl)-L-phenylalanyl]-glycine amide 
• 42567-71-5 L-Phe-Gly-OEt 
• 13122-99-1 (S)-2-(2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)acetic acid 
• 108992-40-1 ((S)-4-benzyl-2,5-dioxo-imidazolidin-1-yl)-acetic acid amide 
• 4526-80-1 Cbz-phenylalanylglycyl hydrazide 
• 35646-66-3 Ts-Phe-Gly-OEt 
• 74075-24-4 Phe-Gly-Pro 
• 74075-20-0 Ts-Phe-Gly 
• 74075-25-5 Bz-Phe-Gly-Pro 
• 74075-22-2 Ts-Phe-Gly-Pro 
• 74075-23-3 Cbz-Phe-Gly-Pro-OBzl 
• 74075-21-1 Ts-Phe-Gly-Pro-OBzl 
• 99592-96-8 H-Tyr-D-Arg-Phe-Gly-Tyr-Pro-Ser-NH₂ 
• 793626-17-2 D-Arg(Tos)-Phe-Gly-OEt 

Relevant academic research and scientific papers

Solar and Visible Light Assisted Peptide Coupling

Amino acid and peptide couplings are widely used in fields related to pharma and materials. Still, current peptide synthesis continues to rely on the use of expensive, water sensitive, and waste-generating coupling reagents, which are often prepared in mu

Scandium(III) triflate-promoted serine/threonine-selective peptide bond cleavage

The site-selective cleavage of peptide bonds is an important chemical modification that is useful not only for the structural determination of peptides, but also as an artificial modulator of peptide/protein function and properties. Here we report site-selective hydrolysis of peptide bonds at the Ser and Thr positions with a high conversion yield. This chemical cleavage relies on Sc(iii)-promoted N,O-acyl rearrangement and subsequent hydrolysis. The method is applicable to a broad scope of polypeptides with various functional groups, including a post-translationally modified peptide that is unsuitable for enzymatic hydrolysis. The system was further extended to site-selective cleavage of a native protein, Aβ1-42, which is closely related to the onset of Alzheimer's disease.

Phosphine-based redox catalysis in the direct traceless staudinger ligation of carboxylic acids and azides

Redox catalysis: Aryl amides, imides, lactams, and dipeptides are obtained through a direct Staudinger ligation mediated by phosphine-based redox catalysis (see scheme). Mechanistic studies indicate the involvement of a phosphonium carboxylate intermediate that leads to a 1,3-acyl migration and thus results in C-N bond formation. Copyright

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild condi

Design, synthesis, and application of enantioselective coupling reagent with a traceless chiral auxiliary

(Chemical Equation Presented) Stable chiral N-triazinylbrucinium tetrafluoroborate enantioselectively activates racemic carboxylic acids yielding enantiomerically enriched amides, esters, and dipeptides with er from 8:92 to 0.5:99.5. Due to the departure

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of t

Microwave accelerated high speed solution synthesis of peptides employing HATU/HOAt

The chemical synthesis of peptides employing HATU/HOAt as a coupling agent under microwave irradiation has been described. The couplings found to be complete in 30-40 s. The yield as well as purity of the peptides made is found to be good. All the peptide

Ethyl propiolate: A simple and convenient peptide coupling reagent

Ethyl propiolate has been used to activate N-protected amino acids to form a moderately activated vinyl-ester which aminolysis requires a catalytic amount of sodium bisulfite.

A new method for the synthesis of carboxamides and peptides using 1,1′-carbonyldioxydi[2(1H)-pyridone] (CDOP) in the absence of basic promoters

Various carboxamides or peptides are synthesized from the corresponding carboxylic acids and amines or α-amino acids using 1,1′-carbonyldioxydi[2(1H)-pyridone]. The reaction proceeds in the absence of basic promoters such as triethylamine or 4-(dimethylamino)pyridine, therefore, the undesired racemization does not occur at all in the segment coupling producing Z-Gly-Phe-Val-OMe and Z-Phe-Val-Ala-OMe.

A convenient method for the preparations of carboxamides and peptides by using di(2-pyridyl) carbonate and O,O′-di(2-pyridyl) thiocarbonate as dehydrating reagents

Preparations of carboxamides and peptides are performed in high yields from free carboxylic acids and amines by dehydration condensation using di(2-Pyridyl) carbonate (DPC) or O,O′-Di(2-Pyridyl) thiocarbonate (DPTC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP). The formation of 2-Pyridyl esters, key intermediates of the reaction, from carboxylic acids by using DPC proceeded faster than by using DPTC; therefore, the former carbonate is more efficiently employed in the above condensation reactions.