27845-47-2Relevant articles and documents
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Parry,K.A.W. et al.
, p. 700 - 703 (1970)
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Direct electrochemical imidation of aliphatic amines via anodic oxidation
Zhang, Li,Su, Ji-Hu,Wang, Sujing,Wan, Changfeng,Zha, Zhenggen,Du, Jiangfeng,Wang, Zhiyong
supporting information; experimental part, p. 5488 - 5490 (2011/06/23)
Direct electrochemical synthesis of sulfonyl amidines from aliphatic amines and sulfonyl azides was realized with good to excellent yields. Traditional tertiary amine substrates were broadened to secondary and primary amines. The reaction intermediates were observed and a reaction mechanism was proposed and discussed.
Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis
Schmidt, Axel M.,Eilbracht, Peter
, p. 5528 - 5535 (2007/10/03)
The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.