278600-50-3

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 109-94-4 formic acid ethyl ester 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 96729-80-5 2-(3,4-dimethoxyphenyl)-3-oxopropanenitrile 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 

Downstream Products

• 1084953-04-7 3-(3,4-dimethoxy-phenyl)-4H-pyrazolo[1,5-a]pyrimidin-5-one 
• 921620-91-9 5-chloromethyl-6-(3-chloro-phenyl)-3-(3,4-dimethoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-7-ylamine 
• 838855-36-0 4-[7,8-bis(methyloxy)-3H-pyrazolo[3,4-c]isoquinolin-5-yl]phenol trifluoroacetate 
• 1084951-40-5 (3-(4-(3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-2-methoxyphenoxy)propyl)carbamic acid tert-butyl ester 
• 1084951-41-6 3-(4-(3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-2-methoxyphenoxy)propylamine 
• 1015480-67-7 5-chloro-3-(3,4-dimethoxy-phenyl)-pyrazolo[1,5-a]pyrimidine 
• 278600-54-7 8-(3,4-dimethoxy-phenyl)-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazin-4-ol 

Relevant academic research and scientific papers

PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.

Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders

The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.

ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE

The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.

Organic compounds

The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES

The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

Design, synthesis, and structure - Activity relationship studies of ATP analogues as DNA gyrase inhibitors

We report herein the design and synthesis of ATP-analogues, namely 4-amino-pyrazolo[3,4-d]pyrimidines and 4-amino-pyrazolo[1,5-a][1,3,5]triazines, with DNA gyrase inhibitory activity. Among these series, some compounds exhibited promising antibacterial activity. (C) 2000 Elsevier Science Ltd. All rights reserved.