27862-73-3Relevant academic research and scientific papers
Metal and Oxidant Free Construction of Substituted- and/or Polycyclic Indoles: A Useful Alternative to Bischler and Related Syntheses
De Crescentini, Lucia,Favi, Gianfranco,Mantellini, Fabio,Mari, Giacomo,Santeusanio, Stefania
supporting information, (2020/08/27)
A wide range of substituted indoles or polycyclic derivatives containing the indole core are easily accessible by acidic treatment of aromatic amines and 1,2-diaza-1,3-dienes. Unlike the related indole-Bischler synthesis, the regioselectivity of the method here reported is unique and predictable, the yields are generally good and also electron withdrawing substituted indoles are smoothly recovered.
RADICAL ADDITION TO IMINIUM ION MEDIATED BY AQUEOUS TITANIUM TRICHLORIDE
Clerici, Angelo,Porta, Ombretta
, p. 165 - 166 (2007/10/02)
Phenyl, acetyl and methyl radicals add to the Cα atom of the iminium ion formed in situ by the titanium-catalysed condensation of N-methylaniline with acetaldehyde.
