814-75-5Relevant articles and documents
Peterson,Indelicato
, p. 531 (1970)
Preparation method of 3-methyl-3-penten-2-one
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Paragraph 0012-0016, (2019/01/08)
The invention discloses a preparation method of 3-methyl-3-penten-2-one. The preparation method comprises the following steps: with butanone as a raw material, performing 3-position halogenation to obtain 3-halobutanone (1), then performing a ketalation reaction to obtain 3-halobutanonediol (2), then performing a Grignard reaction to obtain a Grignard reagent, performing nucleophilic addition on the Grignard reagent and acetaldehyde, and performing intramolecular dehydration under the conditions of acid catalysis and heating to obtain a target product, namely the 3-methyl-3-penten-2-one (3). The preparation method has the advantages of easy obtainment of the raw material, a wide raw material source, simpleness, low preparation cost and suitability for industrial production; by the preparation method, the problems of high preparation cost and difficult industrial production in the prior art are solved.
Design, synthesis and antifungal activity of novel furancarboxamide derivatives
Wen, Fang,Jin, Hong,Tao, Ke,Hou, Taiping
, p. 244 - 251 (2016/05/24)
Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.