27886-67-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-ISO-BUTYL-5-METHYLHYDANTOIN is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Cosmetic and Personal Care Products:
5-ISO-BUTYL-5-METHYLHYDANTOIN is used as a preservative in cosmetic and personal care products to prevent microbial contamination, ensuring product safety and longevity.
Used in Medical Research:
5-ISO-BUTYL-5-METHYLHYDANTOIN is studied for its potential therapeutic applications in treating medical conditions such as epilepsy and sleep disorders, highlighting its potential as a treatment option for neurological disorders.
However, it is crucial to handle 5-ISO-BUTYL-5-METHYLHYDANTOIN with care due to its potential to cause skin and eye irritation. Proper personal protective equipment and well-ventilated areas are necessary during its use to ensure safety.

InChI:InChI=1/C8H14N2O2/c1-5(2)4-8(3)6(11)9-7(12)10-8/h5H,4H2,1-3H3,(H2,9,10,11,12)/t8-/m0/s1

Upstream product

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• 7647-01-0 hydrogenchloride 
• 102539-40-2 4-isobutyl-4-methyl-5-thioxo-imidazolidin-2-one 
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Downstream Products

• 144-24-1 2-amino-2,4-dimethylpentanoic acid 
• 102617-75-4 4-Isobutyl-4-methyl-2,5-dioxo-imidazolidine-1-carbonitrile 
• 13893-50-0 2-amino-2,4-dimethyl-valeric acid ethyl ester 

Relevant academic research and scientific papers

Microwave-promoted facile and rapid synthesis procedure for the efficient synthesis of 5,5-disubstituted hydantoins

A fast, general, environmentally friendly, and facile method for preparation of 5, 5-disubstituted hydantoins from the reaction between ketone (or aldehyde) derivatives with KCN and ammonium carbonate under microwave irradiation is presented. The microwaves remarkably accelerated this reaction, the reaction times decreased dramatically, the reaction conditions were milder, and the yields were also greater. Also a comparative study of microwave versus classical conditions has been done. All the products were characterized by infrared, NMR, and CHN analysis, and their melting points are identical to those of the known compounds reported in the literature. This method might be useful in the future for the preparation of similar derivatives. Taylor & Francis Group, LLC.

A one-pot synthesis of 5,5-disubstituted hydantoin derivatives using magnetic Fe3O4 nanoparticles as a reusable heterogeneous catalyst

A facile and rapid method for the one-pot synthesis of 5,5-disubstituted hydantoins in the presence of magnetic Fe3O4 nanoparticles has been developed. The multicomponent reactions of carbonyl compounds (aldehydes and ketones), potassium cyanide and ammonium carbonate were carried out under solvent-free conditions to obtain various hydantoin derivatives. The magnetic catalyst could be readily separated by an external magnet from the reaction mixture. This procedure has many advantages, such as the use of a reusable magnetic catalyst, high yields, short reaction times, simplicity and very easiness with implementing the methodology.