27895-70-1

Upstream product

• 90-02-8 salicylaldehyde 
• 107-11-9 1-amino-2-propene 

Downstream Products

• 177780-96-0 2-[N-(prop-2'-enyl)aminomethyl]phenol 
• 458568-14-4 allyl-(2-hydroxy-benzyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis, characterization, X-ray crystal structures and antibacterial activities of Schiff base ligands derived from allylamine and their vanadium(IV), cobalt(III), nickel(II), copper(II), zinc(II) and palladium(II) complexes

A new Schiff base ligand, HL2, and four new Schiff base complexes, NiL12, PdL12, NiL22 and ZnL22, have been prepared and characterized by elemental analysis

Plasma deposited metal Schiff-base compounds as antimicrobials

This paper details the synthesis, characterisation including crystal structure, and testing for antimicrobial efficacy of two compounds: a zinc centred bis(N-allylsalicylideneiminato)-zinc (ZSB) and its known copper analogue, bis(N-allylsalicylideneiminat

Synthesis, characterization and X-ray crystal structures of Vanadium(IV), Cobalt(III), Copper(II) and Zinc(II) complexes derived from an asymmetric bidentate Schiff-base ligand at ambient temperature

An asymmetric bidentate Schiff-base ligand (HL: 2-((allylimino)methyl)phenol) was prepared from reaction of salicylaldehyde and Allylamine. Vanadium(IV), Cobalt(III), Copper(II) and Zinc(II) complexes, VOL2, CoL3, CuL2 and ZnL2 were synthesized from the reaction of VO(acac)2, CoCl2·6H2O, CuCl2·2H2O and Zn(NO3)2·6H2O with the bidentate Schiff base ligand (HL: 2-allyliminomethyl-phenol) in methanol at ambient temperature. The ligand and its metal complexes were characterized by elemental analysis (CHN), FT-IR spectroscopy. In addition, 1H and 13C NMR techniques were employed for characterization of the ligand (HL) and diamagnetic complex ZnL2. The molecular structures of all complexes were determined by single crystal X-ray diffraction technique. In the ZnL2 and CuL2 complexes, the metal ion is coordinated by two nitrogen and two oxygen atoms from two Schiff base ligands in an approximately square planar trans-[MN2O2] coordination geometry. In the Vanadium(IV) complex, VOL2, the vanadium center in this structure has a distorted tetragonal pyramidal N2O3 coordination sphere and for Cobalt(III) complex, CoL3, the CoIII ion is six coordinated by three bidentate Schiff base ligands in a distorted octahedral environment.

DNA and HSA interaction of Vanadium (IV), Copper (II), and Zinc (II) complexes derived from an asymmetric bidentate Schiff-base ligand: multi spectroscopic, viscosity measurements, molecular docking, and ONIOM studies

The interaction of three complexes [Zn(II), Cu(II), and V(IV)] derived from an asymmetric bidentate Schiff-base ligand with DNA and HSA was studied using fluorescence quenching, UV–Vis spectroscopy, viscosity measurements, and computational methods?[molec

Dioxomolybdenum(VI) Complexes with R1-Substituted Salicylidene Allylimines (Hln): Synthesis and Structure. Crystal Structure of [MoO2(L1)2] (R1 = H)

The synthesis and X-ray diffraction analysis of [MoO2(L1)2] has been performed. The molybdenum atom has a cis(Ooxo), cis(NL), trans(OL) octahedral coordination. The average bond lengths (?): Mo–O(oxo), 1.691; Mo–N(L1), 2.351; Mo–O(L1), 1.954.

An oxorhenium(V) Schiff-base complex: Synthesis, characterisation, structure, spectroscopic and electrochemical aspects

Reaction of equimolar proportion of trans-ReOCl3(PPh 3)2 with HL, a 1:1 Schiff-base condensate of salicylaldehyde and allylamine, in chloroform gives rise to ReO(L)(PPh 3)Cl2 1a in optimal yield. 1a has been characterized by C, H and N microanalyses, ESI-MS, FT-IR, UV-Vis spectra, molar conductivity measurements. The X-ray crystal structure of 1a reveals that it is an octahedral cis-Cl,Cl oxorhenium(V) complex. The rhenium center is in 'NO 2Cl2P' coordination sphere. 1a crystallizes in the orthorhombic space group Pna21 with a = 17.3541(11), b = 10.2737(6), c = 15.2113(10) ?, V = 2712.0(3) ?3 and Z = 4. The photophysical and electrochemical aspects of 1a have been studied. Electrochemical studies in dichloromethane show Re(V) to Re(VI) oxidation at 1.437 V along with a reduction of Re(V) to Re(IV) at -0.705 V versus Ag/AgCl. Excitation of 1a in chloroform at 460 nm leads to a fluorescent emission at 525 nm with a quantum yield (F) of 0.17. Geometry optimization of the cis-Cl,Cl complex 1a vis-à-vis its trans analogue, trans-Cl,Cl complex 1b, have been performed at the level of the density functional theory (DFT). It is revealed that 1b is more stable than 1a by 4 kcal per mole of energy in gas phase.

Studies of DNA- and HSA-binding properties of new nano-scale green synthesized Ni (II) complex as anticancer agent using spectroscopic methods, viscosity measurement, molecular docking, MD simulation and QM/MM

Herein, we synthesized a new nano-scale Schiff base Ni(II) complex in water as a green solvent and at ambient temperature. The compound was characterized using FT-IR and elemental analysis. Also, its molecular structure was determined by single crystal X-ray diffraction technique. The MTT assay results indicated that the anticancer activity of the compound is affected by its size. Finally, binding ability of the nano-scale Ni(II) Schiff base complex with calf thymus DNA and human serum albumin was investigated using combination of experimental (UV–Vis, fluorescence, circular dichroism (CD) and viscosity) and computational (molecular docking, molecular dynamics simulation and qm/mm) methods. The estimated binding constants for the DNA-complex and HSA-complex were about 104 M? 1. Molecular docking studies revealed the binding of Ni(II) complex to the minor groove of DNA and warfarin binding site of protein by formation of hydrogen bond, π-cation and hydrophobic interactions. MD simulation studies revealed that complexation with NiL2 changed the structure of HSA when compared to free protein. Finally, the ONIOM results showed that the structural parameters of the compound changed along with binding to DNA and HSA, indicating the strong interaction between the compound and these biomacromolecules.

Halloysite functionalized with Cu (II) Schiff base complex containing polymer as an efficient catalyst for chemical transformation

Copper Schiff base complex with allyl functionality was prepared and reacted with amino-functionalized halloysite. The resultant compound was then reacted successively with melamine and the as-prepared copper Schiff base complex to furnish a polymeric moiety with multi copper Schiff base complex on the halloysite outer surface. The latter was then characterized by EDS, FTIR, TGA, ICP, TEM, XRD, VSM and elemental mapping analysis and subsequently applied as a catalyst for promoting one-pot reaction of aldehydes and dimedone to synthesize xanthene derivatives. The catalyst showed high catalytic activity under mild reaction condition and could be easily recovered and efficiently recycled with low Cu leaching. Notably, this protocol could be generalized to various aldehydes with different electron densities.

Observations concerning the synthesis of heteroatom-containing 9-membered benzo-fused rings by ring-closing metathesis

A set of benzo-fused dienes with a 1,9-relationship and containing a variety of nitrogen and oxygen heteroatoms was readily synthesized. These dienes were then treated with the Grubbs second generation catalyst with the aim of synthesizing the 9-membered benzannelated heterocycles containing two heteroatoms (either O,O, NR,NR or O,NR where R = Ts or Boc). As previously observed in the literature, many of the dienes did not give the expected ring-closed product. However, a number of the desired products did form, namely with the 1,2-dihydrobenzo[c][1,5]oxazonin-7(5H)-one, 5,7-dihydrobenzo[b][1,5]oxazonine-6(2H)-carboxylate and 2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine cores, albeit in poor yields. Rather surprisingly, the N-allyl-N-(2-(N-allyl-4-methylphenylsulfonamido)benzyl)-4-methylbenzenesulfonamide scaffold gave the desired ring-closed 1,6-ditosyl-2,5,6,7-tetrahydro-1H-benzo[b][1,5]diazonine in a high yield. Furthermore, when treated with the catalyst [RuClH(CO)(PPh3)3] the alkene isomerized into conjugation only with the benzylic NTs group and not with the phenyl NTs group to afford the 1,6-ditosyl-2,3,6,7-tetrahydro-1H-benzo[b][1,5]diazonine structure.

An efficient microwave method for the synthesis of imines

A large variety of aryl and heterocyclic chiral and achiral imines can be generated simply, efficiently, and cleanly through the use of microwave irradiation and the use of a small amount of molecular sieve. Reactions are rapid and complete in a matter of minutes, and can be quantitative, reducing significantly the time and amount of solvents used in compound isolation and purification.