27897-08-1

Basic information

• Product Name: 2,5-dimethylsulphanilic acid
• Synonyms: 2,5-dimethylsulphanilic acid;4-Amino-2,5-dimethylbenzenesulfonic acid
• CAS NO: 27897-08-1
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.24284
• EINECS: 248-718-5
• Mol File: 27897-08-1.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.368g/cm³
• Refractive Index: 1.595
• CAS DataBase Reference: 2,5-dimethylsulphanilic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethylsulphanilic acid(27897-08-1)
• EPA Substance Registry System: 2,5-dimethylsulphanilic acid(27897-08-1)

Safety Data

• Hazardous Substances Data: 27897-08-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Industry:
2,5-dimethylsulphanilic acid is used as a pH indicator for its ability to change color from yellow to red within the pH range of 0.7-1.8, making it a valuable tool in various chemical processes that require precise pH monitoring.
Used in Textile and Paper Industries:
In the textile and paper industries, 2,5-dimethylsulphanilic acid is utilized as a component in the production of azo dyes. These dyes are known for their wide range of colors and are extensively used in coloring fabrics and paper products.
Used in Pharmaceutical Research:
2,5-dimethylsulphanilic acid is being studied for its potential applications in the treatment of various diseases, including cancer and microbial infections. Its unique chemical structure may offer new avenues for therapeutic intervention, although further research is necessary to establish its efficacy and safety in these contexts.

InChI:InChI=1/C8H11NO3S/c1-5-4-8(13(10,11)12)6(2)3-7(5)9/h3-4H,9H2,1-2H3,(H,10,11,12)

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 19544-68-4 2,5-dimethyl-4-nitro-benzenesulfonic acid 
• 7664-93-9 sulfuric acid 
• 7647-01-0 hydrogenchloride 
• 2050-44-4 N-(2,5-dimethylphenyl)acetamide 

Downstream Products

• 16732-17-5 4-chloro-2,5-dimethyl-benzenesulfonic acid 
• 16732-18-6 4-bromo-2,5-dimethyl-benzenesulfonic acid 
• 88-49-3 4-chloro-2,5-dimethylbenzene-1-sulfonyl chloride 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 
• 104014-86-0 2,5-Dimethyl-1,4-benzenedithiol 
• 104014-87-1 1,4-Bis(2,2-dimethoxyethylthio)-2,5-dimethylbenzene 
• 104014-85-9 4,4'-Dithiobis(2,5-dimethylbenzenesulfonyl Chloride) 

Relevant articles and documents

Sulfonation of arylamines : Part VII-Kinetics of thermal decomposition of tetramethyldianilinium sulfates

Tetramethyldianilinium sulfates (TMDAS) have been prepared and characterised. Thermal decomposition of these salts has been studied by TO and kinetics evaluated using Prout-Tompkins equation. Activation energies of these salts are found to be linearly related to the pKa of the corresponding amine. It has been found that TMDAS give dimethylaminobenzenesulfonic acids (DMAB-SA) via solid state reaction induced by heat. A reaction scheme representing the thermal decomposition pathways of these salts has been suggested. The proton transfer (unimolecular elementary reaction) seems to be the primary step which is followed by a bimolecular step (sulfonalion) for the decomposition of these salts.

Synthesis of Benzodithiophene and its 4,8-Dimethoxy and 4,8-Dimethyl Derivatives

Eine einfache Synthese fuer Benzodithiophen (4) und die Synthese seines bisher unbekannten 4,8-Dimethoxy- (7) and 4,8-Dimethylderivates (13) wird beschrieben.IR-, 1H NMR-, UV- und MS-Daten werden mitgeteilt.

Studies of Reactions of Amines with Sulfur Trioxide. VI. Thermal Reactions of Anilinium, Dimethylanilinium, and Trimethylanilinium Salts of Butylamidosulfuric Acid

When the title compounds were heated in an evacuated reaction vessel, both transsulfonation and rearrangement occurred.At lower temperatures (80-120 deg C) the corresponding phenylamidosulfates and sulfophenylamidosulfates (transsulfonation products) were the main products.Increasing temperature led to the formation of ring mono- and disulfonates (rearrangement products) at the expense of the transsulfonation products.The sulfonate group always migrated to the ortho and/or para position(s) to the amino group.In no case was any meta-product detected.There was no significant difference in the ease of transsulfonation among the anilinium salts studied exept 2,6-dimethyl- and 2,4,6-trimethylanilinium salts.On the other hand, the ease of rearrangement and the orientation of ring sulfonation depended strongly on the structure of the substrate anilines.The thermal reactions of 2,4,6-trimethylanilinium butylamidosulfate produced (2,4,6-trimethylphenylimido)bis(sulfate) in addition to (2,4,6-trimethylphenylamido)sulfate.This is the first isolation of an arylimidobis(sulfate) from such reactions.Mechanisms of the transsulfonation and rearrangement have been discussed.