279229-35-5Relevant articles and documents
Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase
Masubuchi, Miyako,Ebiike, Hirosato,Kawasaki, Ken-Ichi,Sogabe, Satoshi,Morikami, Kenji,Shiratori, Yasuhiko,Tsujii, Shinji,Fujii, Toshihiko,Sakata, Kiyoaki,Hayase, Michiko,Shindoh, Hidetoshi,Aoki, Yuko,Ohtsuka, Tatsuo,Shimma, Nobuo
, p. 4463 - 4478 (2003)
The C-4 side chain modification of lead compound 1 has resulted in the identification of a potent and selective Candida albicans N-myristoyltransferase (CaNmt) inhibitor RO-09-4609, which exhibits antifungal activity against C. albicans in vitro. Further