279231-24-2Relevant academic research and scientific papers
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2
Ebiike, Hirosato,Masubuchi, Miyako,Liu, Pingli,Kawasaki, Kenichi,Sogabe, Satoshi,Hayase, Michiko,Fujii, Toshihiko,Sakata, Kiyoaki,Shindoh, Hidetoshi,Shiratori, Yasuhiko,Aoki, Yuko,Ohtsuka, Tatsuo,Shimma, Nobuo
, p. 607 - 610 (2007/10/03)
Modification of the C-2 position of a benzofuran derivative 6 (RO-09-4609), an N-myristoyltransferase (Nmt) inhibitor, has led us to discover antifungal agents that are active in a murine systemic candidiasis model. The drug design is based on the analysi
