279231-25-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 279231-22-0 [3-(2-hydroxymethyl-3-methyl-benzofuran-4-yloxy)-propyl]-pyridin-3-ylmethyl-carbamic acid tert-butyl ester 
• 279231-23-1 [3-(2-formyl-3-methyl-benzofuran-4-yloxy)-propyl]-pyridin-3-ylmethyl-carbamic acid tert-butyl ester 
• 279229-34-4 (3-methyl-4-{3-[(pyridin-3-ylmethyl)amino]propoxy}benzofuran-2-yl)methanol 
• 279230-20-5 ethyl 3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)benzofuran-2-carboxylate 
• 279231-24-2 [3-(3-methyl-2-styryl-benzofuran-4-yloxy)-propyl]-pyridin-3-ylmethyl-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Bicyclic compounds

The present invention is directed to new bicyclic compounds of the formula [I], and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1Q2and Q3are as defined in the claims. The compounds have N-myristoyltransferase inhibitory and antifungal activity.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2

Modification of the C-2 position of a benzofuran derivative 6 (RO-09-4609), an N-myristoyltransferase (Nmt) inhibitor, has led us to discover antifungal agents that are active in a murine systemic candidiasis model. The drug design is based on the analysi