27925-29-7Relevant articles and documents
Docking studies and α-substitution effects on the anti-inflammatory activity of β-hydroxy-β-arylpropanoic acids
Savic, Jelena S.,Dilber, Sanda P.,Markovic, Bojan D.,Milenkovic, Marina T.,Vladimirov, Sote M.,Juranic, Ivan O.
, p. 6645 - 6655 (2011)
Six β -hydroxy-β -aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen,
Reaction de Reformatsky a froid avec des α-bromoesters-acetals. I. Une methode generale pour la synthese des β-hydroxyacides a partir des α-bromoesters de tetrahydropyrannyle (Note de laboratoire)
Bogavac, M.,Arsenijevic, L.,Arsenijevic, V.
, p. 145 - 147 (2007/10/02)
The readily accessible tetrahydropyranyl esters of α-bromoacids can be used in the Reformatsky reaction for the preparation of β-hydroxyacids.The reaction is generally carried out in cold tetrahydrofuran.The β-hydroxyacids can be easily obtained by stirring the cold solution of their tetrahydropyranyl esters with dilute hydrochloric acid.
