27925-29-7Relevant academic research and scientific papers
Docking studies and α-substitution effects on the anti-inflammatory activity of β-hydroxy-β-arylpropanoic acids
Savic, Jelena S.,Dilber, Sanda P.,Markovic, Bojan D.,Milenkovic, Marina T.,Vladimirov, Sote M.,Juranic, Ivan O.
, p. 6645 - 6655 (2011)
Six β -hydroxy-β -aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen,
Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists
Yang, Bingwei V.,Weinstein, David S.,Doweyko, Lidia M.,Gong, Hua,Vaccaro, Wayne,Huynh, Tram,Xiao, Hai-Yun,Doweyko, Arthur M.,McKay, Lorraine,Holloway, Deborah A.,Somerville, John E.,Habte, Sium,Cunningham, Mark,McMahon, Michele,Townsend, Robert,Shuster, David,Dodd, John H.,Nadler, Steven G.,Barrish, Joel C.
experimental part, p. 8241 - 8251 (2011/02/21)
A series of 2,2-dimethyl-3,3-diphenyl-propanamides as novel glucocorticoid receptor modulators is reported. SAR exploration led to the identification of 4-hydroxyphenyl propanamide derivatives displaying good agonist activity in GR-mediated transrepressio
Reaction de Reformatsky a froid avec des α-bromoesters-acetals. I. Une methode generale pour la synthese des β-hydroxyacides a partir des α-bromoesters de tetrahydropyrannyle (Note de laboratoire)
Bogavac, M.,Arsenijevic, L.,Arsenijevic, V.
, p. 145 - 147 (2007/10/02)
The readily accessible tetrahydropyranyl esters of α-bromoacids can be used in the Reformatsky reaction for the preparation of β-hydroxyacids.The reaction is generally carried out in cold tetrahydrofuran.The β-hydroxyacids can be easily obtained by stirring the cold solution of their tetrahydropyranyl esters with dilute hydrochloric acid.
