2795-61-1

Usage

Derivative of benzoic acid

2-fluorophenoxy group attached to the benzene ring The compound is derived from benzoic acid by attaching a 2-fluorophenoxy group to the benzene ring, which modifies its chemical properties and reactivity.

Use in pharmaceutical industry

Intermediate in the synthesis of various drugs and organic compounds 2-(2-fluorophenoxy)benzoic acid is commonly used as an intermediate in the production of different drugs and organic compounds, making it an important substance in the pharmaceutical industry.

Use as a building block

Production of agrochemicals, dyes, and other organic chemicals The compound is also used as a building block in the synthesis of agrochemicals, dyes, and other organic chemicals, highlighting its versatility in various industries.

Valuable tool for chemical research and development

Due to its properties 2-(2-fluorophenoxy)benzoic acid is a valuable tool in chemical research and development because of its unique properties, which can be exploited to create new compounds and materials.

Potential toxicity

Importance of handling with caution Since 2-(2-fluorophenoxy)benzoic acid has potential toxicity, it is crucial to handle it with care and follow proper safety precautions to avoid adverse effects on human health and the environment.

Upstream product

• 367-12-4 2-fluorophenol 
• 118-91-2 ortho-chlorobenzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 394-47-8 2-fluorobenzonitrile 
• 100-47-0 benzonitrile 

Downstream Products

• 395-92-6 2-(2-fluoro-phenoxy)-benzoic acid methyl ester 
• 81890-63-3 1-<2-(2-fluorophenoxy)phenyl>-4-dimethylaminobutanol 
• 82097-82-3 2-(2-fluorophenoxy)benzaldehyde 
• 81890-62-2 2-(2-fluorophenoxy)benzyl alcohol 

Relevant academic research and scientific papers

Synthesis, fungicidal activity, and 3D-QSAR of tetrazole derivatives containing phenyloxadiazole moieties

In an effort to discover new agents with good fungicidal activities against CDM (cucumber downy mildew), a series of tetrazole derivatives containing phenyloxadiazole moieties were designed and synthesized. The EC50 values for fungicidal activities against CDM were determined. Bioassay results indicated that most synthesized compounds exhibited potential in vivo fungicidal activity against CDM. A CoMFA (comparative molecular field analysis) model based on the bioactivity was developed to identify some primary structural quality for the efficiency. The values of q2 and r2 for the established model were 0.791 and 0.982 respectively, which reliability and predict abilities were verified. Three analogues (q3, q4, q5) were designed and synthesized based on the model. All these compounds exhibited significant fungicidal activity on CDM with the EC50 of 1.43, 1.52, 1.77 mg·L?1. This work could provide a useful instruction for the further structure optimization.

Efficient Aryl Migration from an Aryl Ether to a Carboxylic Acid Group To Form an Ester by Visible-Light Photoredox Catalysis

We have developed a highly efficient aryl migration from an aryl ether to a carboxylic acid group through retro-Smiles rearrangement by visible-light photoredox catalysis at ambient temperature. Transition metals and a stoichiometric oxidant and base are avoided in the transformation. Inspired by the high efficiency of this transformation and the fundamental importance of C?O bond cleavage, we developed a novel approach to the C?O cleavage of a biaryl ether to form two phenolic compounds, as demonstrated by a one-pot, two-step gram-scale reaction under mild conditions. The aryl migration exhibits broad scope and can be applied to the synthesis of pharmaceutical compounds, such as guacetisal. Primary mechanistic studies indicate that the catalytic cycle occurs by a reductive quenching pathway.