27955-44-8

Basic information

• Product Name: 4-METHYL-6-PHENYL-PYRIMIDINE-2-THIOL
• Synonyms: LABOTEST-BB LT00134522;4-METHYL-6-PHENYL-PYRIMIDINE-2-THIOL;2-pyrimidinethiol, 4-methyl-6-phenyl-;4-methyl-6-phenyl-3H-pyrimidine-2-thione
• CAS NO: 27955-44-8
• Molecular Formula: C₁₁H₁₀N₂S
• Molecular Weight: 202.28
• Mol File: 27955-44-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 199-200 °C(Solv: ethanol (64-17-5))
• Boiling Point: 320.5°Cat760mmHg
• Flash Point: 147.6°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.000317mmHg at 25°C
• Refractive Index: 1.642
• PKA: 7.81±0.10(Predicted)
• CAS DataBase Reference: 4-METHYL-6-PHENYL-PYRIMIDINE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-6-PHENYL-PYRIMIDINE-2-THIOL(27955-44-8)
• EPA Substance Registry System: 4-METHYL-6-PHENYL-PYRIMIDINE-2-THIOL(27955-44-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 27955-44-8(Hazardous Substances Data)

Usage

General Description

4-Methyl-6-phenyl-pyrimidine-2-thiol, also known as MPT, is a chemical compound with the molecular formula C12H10N2S. It is a heterocyclic compound with a pyrimidine ring structure and a thiol group attached to the 2-position. MPT is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and potential biological activity. It has been studied for its potential as an anti-cancer agent and has also been investigated for its antioxidant and antimicrobial properties. Additionally, it has been utilized in the development of fluorescent sensors and organic electronic materials. Overall, MPT is a valuable building block in organic synthesis and has potential applications in various fields.

InChI:InChI=1/C11H10N2S/c1-8-7-10(13-11(14)12-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,12,13,14)

Upstream product

• 17356-08-0 thiourea 
• 93-91-4 1-phenylbutan-1,3-dione 
• 6320-47-4 4-methyl-6-phenyl-1⁽³⁾H-pyrimidin-2-one 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 30570-19-5 (4RS)-(±)-3,4-dihydro-6-methyl-4-phenylpyrimidine-2(1H)-thione 
• 122851-95-0 1-(3-imino-1-methyl-3-phenylprop-1-enyl)-5-isothiocyanato-3-methyl-5-phenyl-2-pyrazoline 

Downstream Products

• 17759-27-2 4-methyl-6-phenylpyrimidine 
• 90185-69-6 N,N-dimethyl-2-(4'-methyl-6'-phenylpyrimidin-2'-ylthio)ethylamine 
• 146547-34-4 (4-Methyl-6-phenyl-pyrimidin-2-ylsulfanyl)-acetonitrile 
• 89242-72-8 4-Methyl-2-methylthio-6-phenylpyrimidin-hydroiodid 
• 1012050-82-6 [Ni(4,6-methylphenylpyrimidine-2-thione(-H))2] 
• 1012050-88-2 [Ni(4,6-methylphenylpyrimidine-2-thione(-H))2(2,2'-bipyridine)] 
• 1012050-93-9 [Ni(4,6-methylphenylpyrimidine-2-thione(-H))2(1,10-phenanthroline)] 
• 15755-15-4 2-amino-6-methyl-4-phenylpyrimidine 

Relevant articles and documents

2-Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation

Supernumerary centrosomes are a source of aneuploidy, and cells have adopted different mechanisms to avoid multipolar mitoses. The kinesin HSET is required for pseudo-bipolar mitoses in cancer cells with amplified centrosomes and suppression of HSET activ

Microwave-expedited one-pot, two-component, solvent-free synthesis of functionalized pyrimidines

The synthesis of a series of diversely substituted pyrimidines under solvent-free conditions in good yields is described. Under microwave irradiation, a variety of nucleophilic substrates containing the N?C?N unit with ?-dicarbonyl compounds, ethyl cyanoacetate, malononitrile, and chalcones was cyclized to give pyrimidines. A combinatorial type approach for a one-step synthesis has been developed where a ring-closing condensation is followed by spontaneous aromatization to afford 28 functionalized and aryl/alkyl substituted pyrimidines. CSIRO 2007.

Heterocyclic amplifiers of phleomycin. I. Some pyrimidinylpurines, pyrimidinylpteridines and phenylpyrimidines

-