15755-15-4

Basic information

• Product Name: 4-METHYL-6-PHENYLPYRIMIDIN-2-AMINE
• Synonyms: 4-Methyl-6-phenyl-2-pyrimidinamine;Albb-005380;4-methyl-6-phenylpyrimidin-2-amine(SALTDATA: FREE);CHEMBRDG-BB 4012253;4-METHYL-6-PHENYLPYRIMIDIN-2-AMINE
• CAS NO: 15755-15-4
• Molecular Formula: C₁₁H₁₁N₃
• Molecular Weight: 185.23
• Mol File: 15755-15-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 400ºC at 760 mmHg
• Flash Point: 224.5ºC
• Appearance: /
• Density: 1.159g/cm3
• Vapor Pressure: 1.31E-06mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 4-METHYL-6-PHENYLPYRIMIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-6-PHENYLPYRIMIDIN-2-AMINE(15755-15-4)
• EPA Substance Registry System: 4-METHYL-6-PHENYLPYRIMIDIN-2-AMINE(15755-15-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 15755-15-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 21, p. 65, 1984 DOI: 10.1002/jhet.5570210115

InChI:InChI=1/C11H11N3/c1-8-7-10(14-11(12)13-8)9-5-3-2-4-6-9/h2-7H,1H3,(H2,12,13,14)

Upstream product

• 113-00-8 guanidine nitrate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 106124-30-5 4-Methyl-1-oxy-6-phenyl-pyrimidin-2-ylamine 
• 420-04-2 CYANAMID 
• 89242-72-8 4-Methyl-2-methylthio-6-phenylpyrimidin-hydroiodid 
• 27955-44-8 2-mercapto-6-methyl-4-phenylpyrimidine 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 30570-19-5 (4RS)-(±)-3,4-dihydro-6-methyl-4-phenylpyrimidine-2(1H)-thione 
• 98-86-2 acetophenone 
• 106124-27-0 3-(5-methyl-[1,2,4]oxadiazol-3-ylamino)-1-phenyl-but-2-en-1-one 
• 495-41-0 1-phenylbut-2-en-1-one 
• 50-01-1 guanidine hydrochloride 
• 58006-77-2 4,7-dihydro-7-methyl-5-phenyl-1,2,4-oxadiazepin-3(2H)-one 
• 70769-72-1 1-phenyl-3-ethylsulfenyl-2-buten-1-one 

Downstream Products

• 1104066-55-8 2-(2,6-dibromophenyl)-3-(4-methyl-6-phenylpyrimidin-2-yl)thiazolidin-4-one 
• 663955-81-5 5-iodo-4-methyl-6-phenyl-2-pyrimidinamine 
• 78664-23-0 2-chloro-6-methyl-4-phenylpyrimidine 1-oxide 
• 85658-60-2 2-amino-6-methyl-4-phenylpyrimidine 1-oxide 
• 857621-22-8 N-acetyl-sulfanilic acid-(4-methyl-6-phenyl-pyrimidin-2-ylamide) 

Relevant articles and documents

Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents

A series of 2-(2,6-dihalophenyl)-3-(substituted pyrimidinyl)-1,3-thiazolidin-4-ones were designed on the prediction of quantitative structure-activity relationship (QSAR) studies, synthesized, and evaluated as HIV-1 reverse transcriptase inhibitors. Our attempts in correlating the identified molecular surface features related properties for modeling the HIV-1 RT inhibitory activity resulted in some statistically significant QSAR models with good predictive ability. The results showed that compounds 4m and 4n were highly active in inhibiting HIV-1 replication with EC50 values in the range of 22-28 nM in MT-4 as well as in CEM cells with selectivity indexes of >10,000. The derived models collectively suggest that the compounds should be compact without bulky substitution on its peripheries for better HIV-1 RT inhibitory activity. These models also indicate a preference for hydrophobic compounds to obtain good HIV-1 RT inhibitory activity.

Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines

A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles ac

THE REACTION OF β-AMINOENONES WITH CYANAMIDE. A HIGH EFFICIENT SYNTHESIS OF 2-AMINOPIRIMIDINES.

β-aminoenones react with cyanamide, molar ratio 1:2, to yield 2-aminopyrimidines in nearly quantitative yields.