27958-92-5Relevant articles and documents
Synthesis and antimalarial activity of new analogues of amodiaquine
Delarue-Cochin, Sandrine,Paunescu, Emilia,Maes, Louis,Mouray, Elisabeth,Sergheraert, Christian,Grellier, Philippe,Melnyk, Patricia
, p. 252 - 260 (2008/09/18)
In order to determine the real significance of the 4′-phenolic group in the antimalarial activity and/or cytotoxicity of amodiaquine (AQ), analogues for which this functionality was shifted or modified were synthesized. Good in vitro antimalarial activity
Substituent effects. 14. Anomalous dissociation constants in water-organic solvent mixtures: benzylammonium ions and related systems
Hoefnagel, A. J.,Vos, R. H. de,Wepster, B. M.
, p. 22 - 28 (2007/10/02)
Thermodynamic dissociation constants in various water-organic solvent mixtures are given for benzylammonium, benzyldialkylammonium, and (2-phenylethyl)ammonium ions.Deviations from the Hammett equation (Eqn. 1) are similar to those observed for carboxylic acids, but of opposite sign.The extended Hammett equation (Eqn. 3), containing the hydrophobic constant, ?, yields good correlations.Derived secondary normal sigma values are exemplified.