27974-01-2

Upstream product

• 27906-91-8 N-propyl-2-phenylethylamine 
• 622-24-2 2-phenylethyl chloride 
• 107-10-8 propylamine 
• 103-63-9 1-phenyl-2-bromoethane 
• 100-42-5 styrene 
• 103-80-0 phenylacetyl chloride 
• 71-23-8 propan-1-ol 
• 64-04-0 phenethylamine 

Relevant academic research and scientific papers

Ruthenium-catalyzed N-alkylation of amines with alcohols under mild conditions using the borrowing hydrogen methodology

Using a simple amino amide ligand, ruthenium-catalyzed one-pot alkylation of primary and secondary amines with simple alcohols was carried out under a wide range of conditions. Using the alcohol as solvent, alkylation was achieved under mild conditions, even as low as room temperature. Reactions occurred with high conversion and selectivity in many cases. Reactions can also be carried out at high temperatures in organic solvent with high selectivity using stoichiometric amounts of the alcohol.

Base-catalyzed anti-Markovnikov hydroamination of vinylarenes - Scope, limitations and computational studies

The hydroamination of vinylarenes with primary and secondary amines was studied with catalytic amounts as low as 2 mol-% of LiN(SiMe3) 2/TMEDA. Reactions proceeded readily at 120°C in the absence of solvent to give selective anti-Markovnikov addition. Slow addition was observed at 25°C with either electron-deficient p-chlorostyrene or secondary cyclic amines such as pyrrolidine, piperidine, or morpholine. Primary amines were prone to a second hydroamination reaction to form tertiary amine byproducts. The selectivity for the mono(hydroamination) products could be improved with a two-fold excess of the amine. KN(SiMe3)2 showed higher catalytic activity but lower selectivity in comparison to that of LiN(SiMe 3)2, resulting in undesired C-H-activation by-products. The mechanism of the lithium-catalyzed hydroamination and the influence of TMEDA was studied with density functional theory. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

D2 Dopaminergic and 5-HT1A Serotonergic Activity of 2-(1-Naphthyl)ethyl- and 2-(2-Naphthyl)ethyl Amines

Several tertiary 2-phenylethyl, 2-(1-naphthyl)ethyl and 2-(2-naphthyl) ethyl amines were synthesized and their binding affinities for dopamine D 1, D2 and serotonin 5-HT1A receptors evaluated in radioligand binding assays.