27998-51-2Relevant academic research and scientific papers
A novel synthesis of aryl methyl sulfones and β-hydroxysulfones from sodium sulfinates and di-tert-butyl peroxide in H2O medium
Lai, Junyi,Yuan, Gaoqing
, p. 524 - 527 (2018)
A novel and convenient synthetic route for aryl methyl sulfones and β-hydroxysulfones was developed via the radical reaction between sodium sulfinates and di-tert-butyl peroxide (DTBP). Without any catalysts and additives, the synthetic process could be smoothly carried out to afford the target products in good to excellent yields in H2O medium, demonstrating its promising application. In the present system, H2O could act not only as a green solvent but also as a reactant.
Method for selectively compounding aryl methyl sulphone and belta-hydroxy sulphone derivative
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Paragraph 0037; 0038; 0039, (2017/08/29)
The invention discloses a method for selectively compounding an aryl methyl sulphone and belta-hydroxy sulphone derivative. The method has the advantages that sulfinic acid sodium salt and di-tert-butyl peroxide serve as raw materials, water serves as green reaction solvent, additives and catalysts are not needed, and the aryl methyl sulphone and belta-hydroxy sulphone derivative is obtained through control of reaction temperature selectivity. The method has the advantages of mild reaction condition, simplicity in operation, low cost, environment friendliness, high product selectivity, high yield and the like, and has practical application value.
Direct access to cumbersome aminated quaternary centers by hyperbaric aza-Michael additions
Rulev, Alexander Yu.,Azad, Saleha,Kotsuki, Hiyoshizo,Maddaluno, Jacques
experimental part, p. 6423 - 6429 (2011/02/24)
The aza-Michael addition of secondary amines to α, β or ββdisubstituted α, βunsaturated esters was efficiently achieved under high pressure (10-16 kbar) in protic solvents in the absence of any catalyst. The expected cumbersome β-aminoesters bearing a tertiary amine directly connected to a quaternary carbon atom could be isolated in fair to good yields. By using αβδγ-unsaturated esters (alkyl sorbate), the addition took place regioselectively in a 1,6 manner and afforded the β,γ -unsaturated δ-aminoesters. Copyright
Synthesis and in vitro evaluation of side chain-unsaturated analogs of 24a,24b-dihomo-1,25-dihydroxycholecalciferol
Chodynski, Michal,Wojciechowska, Wanda,Halkes, Sebastian J.,Van De Velde, Jan-Paul,Kutner, Andrzej
, p. 546 - 553 (2007/10/03)
A synthesis and an in vitro evaluation of side chain-unsaturated analogs 3 and 4 of 24a, 24b-dihomo-1,25-dihydroxycholecalciferol (1) are described. Novel C(23a,24)-vitamin D synthons (sulfone 10 and aldehyde 11) were used for the synthesis of analog 4 and for the efficient preparation of the parent compound 1. The synthetic approach developed allows the use of easily available side chain fragments, such as oxirane 12 or Wittig reagent 15 for the preparation of compound 1 and analog 4, respectively. Introduction of a 24aE double bond results in a selective, 1000-fold increase in the binding affinity of analog 4 for the vitamin D receptor, compared to the affinity of 1, whereas the affinity of 4 for the vitamin D-binding protein and the activity in stimulating the differentiation of human promyelocytic leukemia HL-60 cells remained largely unchanged.
New method of preparation of allyl alcohols and its application for synthesis of the side chain of brassinolide
Khripach,Zhabinskii,Zhernosek
, p. 662 - 667 (2007/10/03)
A new method including the stages of formation of unsaturated sulfones and their reduction with lithium metal is suggested for preparation of allyl alcohols. The method was shown to be applicable for constructing the side chain of brassinolide.
