280110-69-2

Basic information

• Product Name: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
• Synonyms: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine;tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate;1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)
• CAS NO: 280110-69-2
• Molecular Formula: C₁₃H₂₁N₃O₃
• Molecular Weight: 267.32414
• Mol File: 280110-69-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 69 °C
• Boiling Point: 384°C at 760 mmHg
• Flash Point: 186.1°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 4.21E-06mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.58±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine(280110-69-2)
• EPA Substance Registry System: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine(280110-69-2)

Safety Data

• Hazardous Substances Data: 280110-69-2(Hazardous Substances Data)

Usage

General Description

1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine, also known as Boc-piperidine, is a chemical compound that belongs to the class of piperidine derivatives. It is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. The "Boc" in its name stands for tert-butoxycarbonyl, which is a protecting group used in organic synthesis. The presence of the oxadiazole ring in its structure gives it potential biological activity, making it an important compound in medicinal chemistry research. Boc-piperidine is commonly used in the pharmaceutical industry as a building block for the synthesis of various medicinally active molecules. Its unique structure and reactivity make it a valuable starting material for the development of new drugs and biologically active compounds.

InChI:InChI=1/C13H21N3O3/c1-9-14-15-11(18-9)10-5-7-16(8-6-10)12(17)19-13(2,3)4/h10H,5-8H2,1-4H3

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 187834-88-4 tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 685827-77-4 tert-butyl 4-(2-acetylhydrazinecarbonyl)piperidine-1-carboxylate. 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 859154-07-7 4-[4-(4-chloro-phenyl)-5-methyl-4H-[1,2,4]triazol-3-yl]-piperidine 
• 859155-62-7 4-[4-(4-chloro-2-methylphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]piperidine 
• 280110-76-1 2-methyl-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride 
• 2442597-61-5 4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine hydrobromide 
• 859154-08-8 4-[4-(4-chloro-phenyl)-5-methyl-4H-[1,2,4]triazol-3-yl]-piperidine hydrochloride 
• 685827-98-9 4-(4-benzyl-5-methyl-4H-[1,2,4]triazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Development of autotaxin inhibitors: A series of tetrazole cinnamides

A series of inhibitors of Autotaxin (ATX) have been developed from a high throughput screening hit, 1a, which shows an alternative binding mode to known catalytic site inhibitors. Selectivity over the hERG channel and microsomal clearance were dependent on the lipophilicity of the compounds, and this was optimised by reduction of clogD whilst maintaining high affinity ATX inhibition. Compound 15a shows good oral exposure, and concentration dependent inhibition of formation of LPA in vivo, as shown in pharmacokinetic-pharmacodynamic (PK/PD) experiments.

AUTOTAXIN INHIBITORS COMPRISING A HETEROAROMATIC RING-BENZYL-AMIDE-CYCLE CORE

The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents a group selected from H, CF3, and C1-6 alkyl (optionally substituted by C1-6 alkyloxy or triazolyl); R2/