280110-70-5

Basic information

• Product Name: tert-Butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
• Synonyms: tert-Butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
• CAS NO: 280110-70-5
• Molecular Formula: C₁₈H₂₃N₃O₃
• Molecular Weight: 329.39352
• Mol File: 280110-70-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate(280110-70-5)
• EPA Substance Registry System: tert-Butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate(280110-70-5)

Safety Data

• Hazardous Substances Data: 280110-70-5(Hazardous Substances Data)

Upstream product

• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 187834-88-4 tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1031156-54-3 tert-butyl 4-(2-benzoylhydrazinecarbonyl)piperidine-1-carboxylate 
• 5333-86-8 ethyl benzimidate hydrochloride 

Downstream Products

• 1004527-75-6 2-phenyl-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride 
• 280110-78-3 4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-piperidine 
• 1419956-62-9 [4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-piperidin-1-yl]-acetic acid 
• 1419951-13-5 C₂₃H₂₆N₆O₄ 

Relevant articles and documents

Discovery of highly potent triazole antifungal agents with piperidine-oxadiazole side chains

Due to increasing incidence and mortality of invasive fungal infections, discovery and development of new generations of antifungal agents represents a challenging task. On the basis of our previously reported triazole-benzyloxypiperidinyl lead compound, a series of novel triazole antifungal agents containing piperidine-oxadiazole side chains were rationally designed and synthesized. Most of the target compounds showed excellent inhibitory activity against clinically important fungal pathogens. In particular, compounds 6g (MIC = 0.031 μg mL-1) and 11b (MIC = 0.016 μg mL-1) were highly active against Candida albicans including fluconazole-resistant strains. Moreover, they showed inhibitory activity against hyphal formation with low toxicity, which were promising leads for further development. This journal is

AZOLE COMPOUND

[Problems] A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. [Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity