28044-44-2 Usage
Chemical structure
A maleate salt derivative of a piperazine compound with a pyrrolidin-1-ylcarbonyl and 3,4,5-trimethoxycinnamoyl groups.
Potential pharmaceutical applications
The compound may have potential uses in the development of drugs for various medical conditions.
Biological activities
The compound is likely to exhibit a wide range of biological activities due to the presence of functional groups in its structure.
Piperazine moiety
Known for its activity as an antipsychotic and antiemetic.
Trimethoxycinnamoyl group
Reported to have antioxidant and anti-inflammatory properties.
Further research and development
The compound may be of interest for further research and development as a potential drug candidate.
Salt form
The compound is in the form of a maleate salt, which can influence its solubility and stability.
Molecular complexity
The compound has a complex molecular structure with multiple functional groups, which may contribute to its potential biological activities.
Potential for drug development
Given its diverse range of biological activities and potential pharmaceutical applications, the compound may be a promising candidate for drug development in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 28044-44-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,0,4 and 4 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28044-44:
(7*2)+(6*8)+(5*0)+(4*4)+(3*4)+(2*4)+(1*4)=102
102 % 10 = 2
So 28044-44-2 is a valid CAS Registry Number.
28044-44-2Relevant academic research and scientific papers
Preparation method for cinepazide maleate
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, (2020/04/17)
The invention provides a preparation method for cinepazide maleate, which comprises the following steps of: (1) carrying out Wittig reaction on 3, 4, 5-trimethoxybenzaldehyde serving as an initial rawmaterial and phosphine ylide to obtain (E)-3, 4, 5-trimethoxyethyl cinnamate (intermediate I), (2) hydrolyzing the (E)-3, 4, 5-trimethoxyethyl cinnamate to obtain a key intermediate 3, 4, 5-trimethoxy cinnamic acid (intermediate II), (3) in the presence of 1-hydroxybenzotriazole, triethylamine and carbodiimide hydrochloride, coupling the intermediate I with anhydrous piperazine to synthesize 1-(3, 4, 5-trimethoxycinnamoyl) piperazine (intermediate III), (4) reacting the 1-(3, 4, 5-trimethoxycinnamoyl) piperazine with 2-bromo-1 (pyrrolidine-1-yl) ethyl ketone to generate cinepazide (an intermediate IV), and (5) salifying the cinepazide in the step (4) and maleic acid to generate the target product cinepazide maleate. The preparation method has the advantages of cheap and easily available raw materials, simple operation, short production period, high yield, easy purification, good control of the product quality, reduction of the pollutant discharge, environmental protection, and realization of industrial production.
