280582-07-2Relevant academic research and scientific papers
Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors
Verma, Sharad,Nagarathnam, Dhanapalan,Shao, Jianxing,Zhang, Lei,Zhao, Jin,Wang, Yamin,Li, Tindy,Mull, Eric,Enyedy, Istvan,Wang, Chunguang,Zhu, Qingming,Altieri, Martha,Jordan, Jerold,Dang, Thu-Thi-Anh,Reddy, Sanjeeva
, p. 1973 - 1977 (2005)
A series of aminobenzimidazole-substituted pyrimidines were synthesized and evaluated for biochemical activity against CDK1. A high-speed parallel synthesis approach enabled the identification of a potent lead series having improved potency in the CDK1 assay (IC50 10 nM). Cell cycle analysis showed that the compounds induced a G2/M block. Docking studies were carried out with a CDK1 homology model, and provide a rationale for the observed activities.
PYRIDINYL AMINO PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS
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Page/Page column 11, (2008/06/13)
The present invention relates to a compound of Formula I(a) or I(b)I(a) I(b)whereinX is halo;R1 is selected from morpholinyl, NHC(O)(C1-C6)alkyl and O-phenyl wherein said phenyl is optionally substituted with a substituent selected from (C1-C6)alkyl, (C1-
