2806-31-7Relevant academic research and scientific papers
Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activated receptor γ3 (PPAR γ3)-selective antagonists based on the helix12-folding inhibition hypothesis
Ohashi, Masao,Gamo, Kanae,Tanaka, Yuta,Waki, Minoru,Beniyama, Yoko,Matsuno, Kenji,Wada, Jun,Tenta, Masafumi,Eguchi, Jun,Makishima, Makoto,Matsuura, Nobuyasu,Oyama, Takuji,Miyachi, Hiroyuki
, p. 53 - 67 (2015/01/08)
Peroxisome proliferator-activated receptor γ3 (PPARγ3) antagonists are candidates for treatment of type 2 diabetes, obesity and osteoporosis. However, few rational design strategies are currently available. Here, we utilized the helix12 (H12)-folding inhi
Enantioselective synthesis of axially chiral phthalides through cationic [Rh1(H8-binap)]-catalyzed cross alkyne cyclotrimerization
Tanaka, Ken,Nishida, Goushi,Wada, Azusa,Noguchi, Keiichi
, p. 6510 - 6512 (2007/10/03)
(Chemical equation presented). Easy access to axially chiral phthalides that bear one or two oxymethylene functionalities is provided by an enantioselective cross alkyne cyclotrimerization in the presence of the cationic complex [Rh1{(S)-H8-binap}]+. The axial chirality is introduced during the formation of the benzene ring with high enantioselectivity.
