280752-67-2

Upstream product

• 6641-64-1 4,5-dichloro-2-nitroaniline 
• 13889-98-0 N-acetylpiperidine 
• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 
• 341497-56-1 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester 
• 280752-60-5 3-[4-[3-(4-acetyl-piperazin-1-yl)-3-oxo-propenyl]-2-chlorophenylsulfanyl]-propionic acid methyl ester 

Downstream Products

• 280750-10-9 (2-chloro-4,5-diaminophenyl)[2-chloro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide 

Relevant academic research and scientific papers

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and immune diseases. Recently, a novel series of p-arylthio cinnamides has been described as potent