280774-03-0

Basic information

• Product Name: 4-Piperidinemethanol,1-(1-methylethyl)-(9CI)
• Synonyms: 4-Piperidinemethanol,1-(1-methylethyl)-(9CI);(1-isopropylpiperidin-4-yl)methanol;4-piperidinemethanol, 1-(1-methylethyl)-;(1-isopropylpiperidin-4-yl)methanol(SALTDATA: FREE);1-(1-Methylethyl)-4-piperidineMethanol;1-Isopropyl-4-piperidinecarbinol;(1-isopropyl-4-piperidinyl)methanol;(1-isopropyl-4-piperidyl)methanol
• CAS NO: 280774-03-0
• Molecular Formula: C₉H₁₉NO
• Molecular Weight: 157.255
• Product Categories: ISOPROPYL
• Mol File: 280774-03-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 223.2°C at 760 mmHg
• Flash Point: 81.6°C
• Appearance: /
• Density: 0.934g/cm³
• Vapor Pressure: 0.0198mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: 4-Piperidinemethanol,1-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinemethanol,1-(1-methylethyl)-(9CI)(280774-03-0)
• EPA Substance Registry System: 4-Piperidinemethanol,1-(1-methylethyl)-(9CI)(280774-03-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 280774-03-0(Hazardous Substances Data)

Usage

Uses

(1-Isopropyl-4-piperidinyl)methanol is a useful reagent in the synthesis of Histamine H3 receptor antagonist.

InChI:InChI=1/C9H19NO/c1-8(2)10-5-3-9(7-11)4-6-10/h8-9,11H,3-7H2,1-2H3

Upstream product

• 154348-17-1 ethyl 1-isopropylpiperidine-4-carboxylate 
• 304-59-6 Rochelle's salt 
• 6457-49-4 4-piperidinemethanol 
• 67-64-1 acetone 

Downstream Products

• 280774-04-1 1-Isopropylpiperidine-4-carboxaldehyde 
• 465615-85-4 (4-Bromophenyl)-[2-(1-isopropyl-piperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]-methanone 
• 869002-56-2 4-{5-[(3-fluoro-phenyl)-(tert-butyl-dimethyl-silanyloxy)-methyl]-1-methyl-1H-imidazol-2-yloxymethyl}-1-isopropyl-piperidine 
• 465615-69-4 (4-chlorophenyl)-[2-(1-isopropylpiperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]methanone 

Relevant articles and documents

A scalable synthesis of a histamine H3 receptor antagonist

Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane.

AROMATIC AMIDES

This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.