280781-39-7

Basic information

• Product Name: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-b-phenyl-D-phenylalanyl-N-[(5-cyano-2- thienyl)methyl]-
• CAS NO: 280781-39-7
• Molecular Formula: C31H34N4O4S
• Molecular Weight: 558.701
• Mol File: 280781-39-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-b-phenyl-D-phenylalanyl-N-[(5-cyano-2- thienyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-b-phenyl-D-phenylalanyl-N-[(5-cyano-2- thienyl)methyl]-(280781-39-7)
• EPA Substance Registry System: L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-b-phenyl-D-phenylalanyl-N-[(5-cyano-2- thienyl)methyl]-(280781-39-7)

Safety Data

• Hazardous Substances Data: 280781-39-7(Hazardous Substances Data)

Upstream product

• 138971-65-0 N-(tert-butyloxycarbonyl)-D-3,3-diphenylalanyl-L-proline 
• 227279-10-9 2-cyano-5-(aminomethyl)thiophene 
• 172349-10-9 5-(aminomethyl)thiophene-2-carbonitrile hydrochloride 
• 765-58-2 2-bromo-5-methyl thiophene 
• 72835-25-7 2-cyano-5-methylthiophene 
• 134135-41-4 5-(bromomethyl)thiophene-2-carbonitrile 
• 201799-21-5 5-(N,N-Boc₂-aminomethyl)thiophene-2-carbonitrile 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 79387-71-6 (5-bromothien-2-yl)methanol 
• 172349-09-6 5-(hydroxymethyl)thiophene-2-carbonitrile 

Downstream Products

• 785764-66-1 D-diphenylalanyl-L-prolyl-[(5-cyano-2-thienyl)methyl]amide 
• 280781-37-5 (S)-1-((R)-2-Methanesulfonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (5-cyano-thiophen-2-ylmethyl)-amide 
• 280781-54-6 N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl-[(5-cyano-2-thienyl)methyl]amide 
• 280781-41-1 ((R)-1-{(S)-2-[(5-Cyano-thiophen-2-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid methyl ester 
• 280781-34-2 N-aminosulfonyl-D-diphenylalanyl-L-prolyl-[(5-cyano-2-thienyl)methyl]amide 
• 280781-82-0 N-[2-(methoxycarbonyl)ethyl]-D-diphenylalanyl-L-propyl[(5-cyano-2-thienyl)methyl]amide 
• 280780-95-2 2-{[(1R)-2-((2S)-2{[({5-[amino(imino)methyl]-2-thienyl}methyl)amino]carbonyl}-pyrrolidinyl)-1-benzhydryl-2-oxoethyl]amino}acetic acid 
• 280781-55-7 N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide 

Relevant articles and documents

PEPTIDIC THROMBIN INHIBITOR COMPOUND

The present invention relates to a novel thrombin inhibitor compound which has a good inhibitory effect against thrombosis and can be orally administered, a process for preparing the same, and to a composition for the therapeutic and/or prophylactic treatment of various diseases associated with thrombin inhibition mechanism, which comprises the same as an active ingredient.

Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1

A series of noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1 was investigated. While the amidrazone and the amine series displayed limited oral absorption, the amidine series demonstrated generally good oral absorption and strong antithrombotic activity; the single-digit picomolar Ki achieved from this series is among the best yet reported. The present work highlights the benzamidine compound 11f (LB30812) that exhibits excellent overall profiles of potency, oral absorption and antithrombotic efficacy.