28097-07-6

Upstream product

• 3196-56-3 1-methyl-4-phospha-3,5,8-trioxa-bicyclo<2,2,2>octane-4-sulfide 
• 67-56-1 methanol 
• 106019-48-1 (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-hydrazine 
• 106019-47-0 (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-hydrazine 

Downstream Products

• 36912-27-3 trans-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane 
• 36912-30-8 5-Chloromethyl-5-methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 36895-18-8 5-Chloromethyl-5-methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 36912-38-6 trans-2-(p-Nitrophenyl)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinan 
• 36912-24-0 (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-(4-methoxy-phenyl)-amine 
• 36912-23-9 (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine 
• 28097-12-3 cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane 
• 78266-93-0 5-Chloromethyl-2-(3,5-dimethoxy-phenoxy)-5-methyl-[1,3,2]dioxaphosphinane 2-oxide 
• 78266-92-9 5-Chloromethyl-2-(3,5-dimethoxy-phenoxy)-5-methyl-[1,3,2]dioxaphosphinane 2-oxide 
• 74737-10-3 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide 
• 74737-11-4 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2c-oxide 
• 36912-33-1 cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane 
• 36912-34-2 trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane 
• 36912-31-9 cis-2-<(p-methoxyphenyl)oxy>-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane 

Relevant academic research and scientific papers

Phosphorochloridates from phosphorohydrazides with ButOCl: Stereospecificity, selectivity and phosphorylium ion intermediates

The efficiency with which a six-membered cyclic phosphorochloridate can be obtained from the corresponding hydrazide with retention of configuration at phosphorus, using tert-butyl hypochlorite in tert-butyl alcohol, depends on how stereoelectronic factors influence the fate of an intermediate chloride-phosphorylium ion pair.

Reaction of 2-Ethoxy-5-methyl-1,3,2-dioxaphosphorinane-5-methanol 2-Sulfide and 4-Methyl-2,6,7-trioxa-1-phosphabicyclooctane 1-Sulfide with Sulfuryl Chloride: Mechanistic and Stereochemical Considerations

Treatment of either cis- or trans-2-ethoxy-5-methyl-1,3,2-dioxaphosphorinane-r-5-methanol 2-sulfide with SO2Cl2 yielded the cyclization product 4-methyl-2,6,7-trioxa-1-phosphabicyclooctane 1-oxide.In contrast, treatment of 4-methyl-2,6,7-trioxa-1-phosphabicyclooctane 1-sulfide with the same reagent gave stereospecific ring opening to trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide.