281232-81-3

Basic information

• Product Name: 2-(5-indolyl)ethanol
• Synonyms: 2-(5-indolyl)ethanol
• CAS NO: 281232-81-3
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161
• Mol File: 281232-81-3.mol

Chemical Properties

• Boiling Point: 357.8±17.0 °C(Predicted)
• Appearance: /
• Density: 1.219±0.06 g/cm3(Predicted)
• PKA: 14.93±0.10(Predicted)
• CAS DataBase Reference: 2-(5-indolyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-indolyl)ethanol(281232-81-3)
• EPA Substance Registry System: 2-(5-indolyl)ethanol(281232-81-3)

Safety Data

• Hazardous Substances Data: 281232-81-3(Hazardous Substances Data)

Upstream product

• 77132-99-1 5-ethenyl-1H-indole 
• 75-21-8 oxirane 
• 10075-50-0 5-bromo-1H-indole 
• 1196-69-6 1H-indole-5-carboxaldehyde 

Relevant articles and documents

The indole side chain of tryptophan as a versatile π-donor

Single-armed, 15- and 18-membered lariat ether receptor systems having indolylethyl side arms bind Na+ and K+ in the ring. The indole residue serves as a π-donor to the ring-bound cation. Whether the five- or six-membered ring intera

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said che

Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors

3-Acyl-indole derivative 1 was identified as a novel dengue virus (DENV) inhibitor from a DENV serotype 2 (DENV-2) phenotypic antiviral screen. Extensive SAR studies led to the discovery of new derivatives with improved DENV-2 potency as well as activity in nanomolar to micromolar range against the other DENV serotypes. In addition to the potency, physicochemical properties and metabolic stability in rat and human microsomes were improved during the optimization process. Chiral separation of the racemic mixtures showed a clear preference for one of the two enantiomers. Furthermore, rat pharmacokinetics of two compounds will be discussed in more detail, demonstrating the potential of this new series of pan-serotype-DENV inhibitors.

SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.