77132-99-1

Upstream product

• 68742-28-9 5-ethyl-1H-indole 
• 37033-93-5 5-ethyl-1H-indole-2-carboxylic acid 
• 37033-94-6 ethyl 5-ethylindole-2-carboxylate 

Downstream Products

• 1613685-84-9 (E)-N-(2-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide 
• 68742-28-9 5-ethyl-1H-indole 
• 1416980-12-5 (E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone 
• 1416977-96-2 (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide 
• 1416980-11-4 (E)-tert-Butyl (2-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)carbamate 
• 1416980-10-3 (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indole 
• 1416980-09-0 (E)-tert-Butyl 5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indole-1-carboxylate 
• 281232-81-3 2-(1H-indol-5-yl)ethan-1-ol 

Relevant academic research and scientific papers

SYNTHESIS OF 5-VINYLINDOLE BY SIMULTANEOUS DEHYDROGENATION AND DECARBOXYLATION OF 5-ETHYL-INDOLE-2-CARBOXYLIC ACID AND ITS ETHYL ESTER

A new method is proposed for the synthesis of 5-vinylindole by simultaneous catalytic dehydrogenation and decarboxylation of 5-ethylindole-2-carboxylic acid and its ethyl ester, making it possible to more than double the yield of the previously described method.

SYNTHESIS OF 5-VINYLINDOLE

A convenient method was developed for the synthesis of previously undescribed 5-vinylindole by catalytic dehydrogenation of 5-ethylindole.The effects of the temperature, the amount of catalyst, and the concentration of 5-ethylindole on the yield of the reaction products were investigated.The possibility of obtaining the 5-ethylindole used for dehydrogenation by heterogeneous-catalytic indolization of acetaldehyde p-ethylphenylhydrazone at aluminium oxide was investigated, and favourable conditions were found for this process.